Popov A M, Anisimov M M, Ivanov A S, Korepanova E A, Antonov V F
Antibiotiki. 1982 Apr;27(4):276-80.
The membrane activity of 6 triterpenic glycosides was studied with respect to ionic permeability of the liposomes and flat bilayer lipid membranes. It was shown that the rate of the glycoside effect depended on both the sterol level in the membrane and the sterol type (cholesterol, ergosterol). The activity of cauloside C, a plant glycoside markedly depended on pH of the medium. The carbohydrate chain played an important role in the membrane activity of the glycosides. Correlation in the effect of triterpenic glycosides on the model lipid and cell membranes was noted.
研究了6种三萜糖苷对脂质体和平面双层脂质膜离子通透性的膜活性。结果表明，糖苷作用的速率取决于膜中的甾醇水平和甾醇类型（胆固醇、麦角固醇）。植物糖苷考罗皂苷C的活性明显取决于介质的pH值。糖链在糖苷的膜活性中起重要作用。注意到三萜糖苷对模型脂质膜和细胞膜的作用具有相关性。
