Mats M N, Korkhov V V, Stepanov V R, Kupera E V, Oleĭnikova G K, Anisimov M M
Farmakol Toksikol. 1990 Mar-Apr;53(2):45-7.
The sum of triterpene glycosides of the Far Eastern holothurian Stichopus japonicus Selenka (holotoxins A1 and B1) possesses the contraceptive activity. Glycoside holoturin A of the tropical holothurian Holoturia atra lacks these properties. The action of the sum of holotoxins is based on the estrogenic activity which was demonstrated both in the uterotropic and vaginotropic tests. The drug under study suppresses ovulation and stimulates the contractile activity of the uterus.
远东海参刺参（海参毒素A1和B1）的三萜糖苷总和具有避孕活性。热带海参糙海参的糖苷海参毒素A缺乏这些特性。海参毒素总和的作用基于雌激素活性，这在子宫向性和阴道向性试验中均得到证实。所研究的药物可抑制排卵并刺激子宫的收缩活性。
