Ljunggren B, Möller H
Acta Derm Venereol. 1977;57(4):325-9.
A large number of phenothiazines and chemically related tricyclic drugs have been studied with respect to their phototoxic potency. Two methods were used, an in vivo technique based on the inflammatory response of the mouse tail after systemic administration of the drug plus UVA irradiation, and an in vitro method based on growth inhibition of Candida albicans. Of 27 commercial tricyclic drugs tested in vivo, the most potent were chlorpromazine and two other chlorinated compounds, prochlorperazine and perphenazine. Tricyclic drugs lacking nitrogen, sulphur, or both in their ring system showed no activity. All compounds phototoxic in the mouse were so in the yeast test as well. Here, however, the thioxanthenes (lacking nitrogen) were also highly active.
人们已经对大量的吩噻嗪类药物和化学结构相关的三环类药物的光毒性效力进行了研究。采用了两种方法，一种体内技术是基于在全身给药该药物并进行紫外线A照射后小鼠尾巴的炎症反应，另一种体外方法是基于白色念珠菌的生长抑制。在体内测试的27种市售三环类药物中，效力最强的是氯丙嗪以及另外两种含氯化合物，即丙氯拉嗪和奋乃静。在其环系统中缺乏氮、硫或两者的三环类药物没有活性。在小鼠体内具有光毒性的所有化合物在酵母测试中也具有光毒性。然而，在此测试中，硫杂蒽类（不含氮）也具有高活性。
