Ljunggren B, Möller H
J Invest Dermatol. 1977 May;68(5):313-7. doi: 10.1111/1523-1747.ep12494582.
Chlorpromazine (CPZ) metabolites were studied for their phototoxic potency with the mouse tail technique. The demethylated metabolites were more phototoxic potency with the mouse tail technique. The demethylated metabolites were more phototoxic than CPZ, while CPZ-sulfoxide, 7-hydroxy-CPZ, and 2-chlorphenothiazine were less phototoxic. The phototoxicity of CPZ and desmethyl-CPZ preexposed to UVA was lost, while that of CPZ-sulfoxide was retained. By thin-layer chromatography, CPZ-sulfoxide and promazine were identified as photoproducts of CPZ; the sulfoxide was fairly stable to radiation.
采用小鼠尾巴技术研究了氯丙嗪（CPZ）代谢物的光毒性。去甲基化代谢物在小鼠尾巴技术中具有更强的光毒性。去甲基化代谢物比CPZ的光毒性更强，而CPZ-亚砜、7-羟基-CPZ和2-氯吩噻嗪的光毒性较小。预先暴露于UVA的CPZ和去甲基氯丙嗪的光毒性消失，而CPZ-亚砜的光毒性得以保留。通过薄层色谱法，CPZ-亚砜和丙嗪被鉴定为CPZ的光产物；亚砜对辐射相当稳定。
