Ramis J, Planas J
Avian Dis. 1982 Jan-Mar;26(1):107-17.
A single phenylhydrazine injection (1.8 mg/kg body weight in chickens and 2.2 mg/kg body weight in pigeons) was administered intramuscularly to different lots of animals. The modification of hematocrit, hemoglobin, erythrocyte number, reticulocyte concentration, plasma iron, and total iron-binding capacity was monitored versus time. Depression of the hematological parameters in chickens was greatest on the second day (27-40%), and the values returned to normal by day 7. The drop in pigeons was greater (28-51%) and took longer to return to normal (day 22). The highest percentage of reticulocytes was 35-37%. A plasma iron increase was concomitant to cell destruction and decreased later. The plasma iron clearance values showed a double slope line as a result of the presence of reticulocytes. A high correlation existed between iron uptake by red blood cells at 5 min and the reticulocyte concentration. The responses of the two species to the phenylhydrazine were similar, and differences were more quantitative than qualitative. Reticulocytes were present in normal pigeons, which introduces an important variant in iron metabolism in birds.
对不同批次的动物进行肌肉注射单次苯肼（鸡的剂量为1.8毫克/千克体重，鸽子的剂量为2.2毫克/千克体重）。随时间监测血细胞比容、血红蛋白、红细胞数量、网织红细胞浓度、血浆铁和总铁结合力的变化。鸡的血液学参数在第二天下降最为明显（27%-40%），到第7天数值恢复正常。鸽子的下降幅度更大（28%-51%），恢复正常所需时间更长（第22天）。网织红细胞的最高百分比为35%-37%。血浆铁的增加与细胞破坏同时发生，随后下降。由于网织红细胞的存在，血浆铁清除值呈现双斜率线。5分钟时红细胞对铁的摄取与网织红细胞浓度之间存在高度相关性。两个物种对苯肼的反应相似，差异更多体现在数量上而非质量上。正常鸽子中存在网织红细胞，这在鸟类铁代谢中引入了一个重要变量。
