Evidence against involvement of cytochrome P-450 haem in the regulation of synthesis of mammalian liver 5-aminolaevulinate synthase.
作者信息
Badawy A A
出版信息
Biochem J. 1982 Mar 15;202(3):807-8. doi: 10.1042/bj2020807.
Abstract
摘要
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Evidence against involvement of cytochrome P-450 haem in the regulation of synthesis of mammalian liver 5-aminolaevulinate synthase.关于细胞色素P - 450血红素参与哺乳动物肝脏5 - 氨基酮戊酸合酶合成调控的反对证据。
Biochem J. 1982 Mar 15;202(3):807-8. doi: 10.1042/bj2020807.
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Evidence that in chick embryos destruction of hepatic microsomal cytochrome P-450 haem is a general mechanism of induction of delta-aminolaevulinate synthase by porphyria-causing drugs.有证据表明，在鸡胚中，肝微粒体细胞色素P - 450血红素的破坏是卟啉症致病药物诱导δ-氨基乙酰丙酸合酶的一般机制。
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A model for the regulation of delta-aminolaevulinate synthetase induction in rat liver.大鼠肝脏中δ-氨基乙酰丙酸合成酶诱导调控模型
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Role of haem in the induction of cytochrome P-450 by phenobarbitone. Studies in chick embryos in ovo and in cultured chick embryo hepatocytes.血红素在苯巴比妥诱导细胞色素P-450中的作用。对鸡胚在体及培养的鸡胚肝细胞的研究。
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Effect of haem on cytochrome P-450 synthesis.血红素对细胞色素P - 450合成的影响。
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Differential responses to inducers of delta-aminolaevulinate synthase and haem oxygenase during pregnancy.孕期对δ-氨基乙酰丙酸合酶和血红素加氧酶诱导剂的不同反应。
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Induction of 5-aminolaevulinate synthase by two- to five-carbon alcohols in cultured chick-embryo hepatocytes. Relationship to induction of cytochrome P-450.二至五碳醇对培养的鸡胚肝细胞中5-氨基乙酰丙酸合酶的诱导作用。与细胞色素P-450诱导的关系。
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Hereditary tyrosinemia and the heme biosynthetic pathway. Profound inhibition of delta-aminolevulinic acid dehydratase activity by succinylacetone.遗传性酪氨酸血症与血红素生物合成途径。琥珀酰丙酮对δ-氨基乙酰丙酸脱水酶活性的深度抑制。
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本文引用的文献
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The influence of allyl isopropyl acetamide on d-aminolevulinic acid synthetase and cytochrome P-450.烯丙基异丙基乙酰胺对d-氨基乙酰丙酸合成酶和细胞色素P-450的影响。
Acta Biol Med Ger. 1980;39(1):107-112.
2
Tryptophan pyrrolase in haem regulation. The mechanism of the permissive effect of cortisol on the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide in the adrenalectomized-rat liver.血红素调节中的色氨酸吡咯酶。皮质醇对2-烯丙基-2-异丙基乙酰胺增强去肾上腺大鼠肝脏中5-氨基酮戊酸合酶活性的允许作用机制。
Biochem J. 1980 Mar 15;186(3):993-6. doi: 10.1042/bj1860993.
3
Role of haem in the induction of cytochrome P-450 by phenobarbitone. Studies in chick embryos in ovo and in cultured chick embryo hepatocytes.血红素在苯巴比妥诱导细胞色素P-450中的作用。对鸡胚在体及培养的鸡胚肝细胞的研究。
Biochem J. 1981 Aug 15;198(2):321-9. doi: 10.1042/bj1980321.
4
Iron and the liver. Acute and long-term effects of iron-loading on hepatic haem metabolism.铁与肝脏。铁负荷对肝脏血红素代谢的急性和长期影响。
Biochem J. 1981 Apr 15;196(1):57-64. doi: 10.1042/bj1960057.
5
Differential responses to inducers of delta-aminolaevulinate synthase and haem oxygenase during pregnancy.孕期对δ-氨基乙酰丙酸合酶和血红素加氧酶诱导剂的不同反应。
Biochem J. 1981 Aug 15;198(2):403-8. doi: 10.1042/bj1980403.
6
Tryptophan pyrrolase in haem regulation. The relationship between the depletion of rat liver tryptophan pyrrolase haem and the enhancement of 5-aminolaevulinate synthase activity by 2-allyl-2-isopropylacetamide.色氨酸吡咯酶在血红素调节中的作用。大鼠肝脏色氨酸吡咯酶血红素的消耗与2-烯丙基-2-异丙基乙酰胺对5-氨基酮戊酸合酶活性增强之间的关系。
Biochem J. 1980 Mar 15;186(3):763-72. doi: 10.1042/bj1860763.
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Loss of haem in rat liver caused by the porphyrogenic agent 2-allyl-2-isopropylacetamide.由致卟啉剂2-烯丙基-2-异丙基乙酰胺引起的大鼠肝脏血红素损失。
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Stimulation of liver 5-aminolaevulinate synthetase by drugs and its relevance to drug-induced accumulation of cytochrome P-450. Studies with phenylbutazone and 3,5-diethoxycarbonyl-1,4-dihydrocollidine.药物对肝脏5-氨基酮戊酸合成酶的刺激作用及其与药物诱导的细胞色素P-450蓄积的关系。保泰松和3,5-二乙氧羰基-1,4-二氢可力丁的研究
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A model for the regulation of delta-aminolaevulinate synthetase induction in rat liver.大鼠肝脏中δ-氨基乙酰丙酸合成酶诱导调控模型
Biochem J. 1973 Aug;134(4):847-57. doi: 10.1042/bj1340847.
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The effect of exogenous -aminolaevulinate on rat liver haem and cytochromes.外源性δ-氨基乙酰丙酸对大鼠肝脏血红素和细胞色素的影响。
Biochem J. 1972 Oct;129(5):1095-9. doi: 10.1042/bj1291095.
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