Moore L
Biochem Pharmacol. 1982 Apr 1;31(7):1465-7. doi: 10.1016/0006-2952(82)90050-8.
This work has shown that CS2 promptly inhibits the liver ER calcium pump only in those animals that subsequently develop hepatic necrosis. In this respect, inhibition of the ER calcium pump by CS2 resembles the actions of chlorinated hydrocarbon hepatotoxins. This lends further support to the suggestion that disruption of calcium homeostasis is an important early step in the action of at least some hepatotoxins [1-5]. CS2 appears to be the first example of a hepatotoxin other than chlorinated hydrocarbons that inhibit the liver ER calcium pump early in the course of intoxication. Finally, studies by others [17,18] suggest a mechanism by which CS2 can interact with and inhibit the liver ER calcium pump.
这项研究表明，二硫化碳（CS2）仅在随后发生肝坏死的动物中迅速抑制肝脏内质网钙泵。在这方面，CS2对内质网钙泵的抑制作用类似于氯代烃类肝毒素的作用。这进一步支持了以下观点：钙稳态的破坏是至少某些肝毒素作用过程中的一个重要早期步骤[1-5]。CS2似乎是除氯代烃类之外，在中毒早期抑制肝脏内质网钙泵的肝毒素的首个实例。最后，其他研究[17,18]提出了一种CS2能够与肝脏内质网钙泵相互作用并抑制其功能的机制。
