1,1-二氯乙烯对肝脏内质网钙泵功能的抑制作用。
1,1-Dichloroethylene inhibition of liver endoplasmic reticulum calcium pump function.
作者信息
Moore L
出版信息
Biochem Pharmacol. 1982 Apr 1;31(7):1463-5. doi: 10.1016/0006-2952(82)90049-1.
PMID:7092937
Abstract
This study shows that 1,1-DCE promptly inhibits a calcium homeostatic function of liver ER. The correlation with GSH depletion and the effect of MFOS induction on calcium pump inhibition suggest that this is a direct effect of a 1,1-DCE metabolite on the calcium pump. As a result of calcium pump inhibition, calcium released from the ER may serve to trigger changes that result in a massive influx of extracellular calcium and, ultimately, cytotoxicity.
摘要
本研究表明，1,1-二氯乙烷迅速抑制肝脏内质网的钙稳态功能。与谷胱甘肽耗竭的相关性以及多功能氧化酶诱导对钙泵抑制的影响表明，这是1,1-二氯乙烷代谢产物对钙泵的直接作用。由于钙泵受到抑制，从内质网释放的钙可能引发一系列变化，导致细胞外钙大量内流，并最终引起细胞毒性。
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