Timmis A D, Fowler M B, Jaggarao N S, Vincent R, Chamberlain D A
Br J Clin Pharmacol. 1982 Jun;13(1 Suppl):111S-114S. doi: 10.1111/j.1365-2125.1982.tb01898.x.
1 The role of labetalol in managing acute myocardial infarction is reviewed. 2 After intravenous infusion labetalol lowers blood pressure in patients with increased blood pressure associated with acute myocardial infarction. 3 Although average heart rate was decreased, cardiac index fell only slightly and stroke index was substantially unchanged. 4 In patients whose pretreatment pulmonary artery end-diastolic pressures were increased, labetalol induced decreases, whereas in the presence of normal pressures, these were unchanged. 5 It is concluded that labetalol infusion in patients with acute myocardial infarction is unlikely to precipitate heart failure and is likely to be of value in reducing myocardial oxygen requirement.
回顾了拉贝洛尔在急性心肌梗死治疗中的作用。
静脉输注后，拉贝洛尔可降低急性心肌梗死伴血压升高患者的血压。
虽然平均心率下降，但心脏指数仅略有下降，每搏指数基本不变。
对于治疗前肺动脉舒张末期压力升高的患者，拉贝洛尔可使其降低，而在压力正常的患者中，这些压力则保持不变。
得出结论，在急性心肌梗死患者中输注拉贝洛尔不太可能引发心力衰竭，且可能在降低心肌氧需求方面具有价值。
