硝苯地平或拉贝洛尔在伴有心绞痛的高血压治疗中作为β受体阻滞剂替代药物的作用
Alternatives to beta-blockade in therapy of hypertension with angina pectoris: role of nifedipine or of labetalol.
作者信息
Opie L H, White D, Lee J, Lubbe W F
出版信息
Br J Clin Pharmacol. 1982 Jun;13(1 Suppl):115S-122S. doi: 10.1111/j.1365-2125.1982.tb01899.x.
Abstract
1 Patients with combined hypertension and angina pectoris may represent a therapeutic dilemma, with the angina being refractory to conventional beta-blockade. 2 The added benefit of peripheral vasodilation in control of blood pressure is documented in the case of nifedipine. 3 Improved blood pressure control by added nifedipine may not be accompanied by decreased severity of angina pectoris, emphasizing the complex causation of the angina in such patients. 4 The clinically proven added alpha-blocking activity of labetalol distinguishes labetalol from other beta-blockers. However, the suggested benefits of the added alpha-activity in patients with hypertension and angina remain to be proven by further trials in patients.
摘要
- 合并高血压和心绞痛的患者可能面临治疗困境，其心绞痛对传统β受体阻滞剂治疗无效。2. 硝苯地平可使外周血管扩张，有助于控制血压，这一额外益处已得到证实。3. 加用硝苯地平虽能更好地控制血压，但心绞痛的严重程度可能并未减轻，这凸显了此类患者心绞痛病因的复杂性。4. 拉贝洛尔具有临床证实的额外α受体阻滞活性，这使其有别于其他β受体阻滞剂。然而，拉贝洛尔额外的α受体阻滞活性对高血压合并心绞痛患者的潜在益处仍有待进一步临床试验证实。
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Alternatives to beta-blockade in therapy of hypertension with angina pectoris: role of nifedipine or of labetalol.硝苯地平或拉贝洛尔在伴有心绞痛的高血压治疗中作为β受体阻滞剂替代药物的作用
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引用本文的文献
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