• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

硝苯地平或拉贝洛尔在伴有心绞痛的高血压治疗中作为β受体阻滞剂替代药物的作用

Alternatives to beta-blockade in therapy of hypertension with angina pectoris: role of nifedipine or of labetalol.

作者信息

Opie L H, White D, Lee J, Lubbe W F

出版信息

Br J Clin Pharmacol. 1982 Jun;13(1 Suppl):115S-122S. doi: 10.1111/j.1365-2125.1982.tb01899.x.

DOI:10.1111/j.1365-2125.1982.tb01899.x
PMID:7093094
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1401829/
Abstract

1 Patients with combined hypertension and angina pectoris may represent a therapeutic dilemma, with the angina being refractory to conventional beta-blockade. 2 The added benefit of peripheral vasodilation in control of blood pressure is documented in the case of nifedipine. 3 Improved blood pressure control by added nifedipine may not be accompanied by decreased severity of angina pectoris, emphasizing the complex causation of the angina in such patients. 4 The clinically proven added alpha-blocking activity of labetalol distinguishes labetalol from other beta-blockers. However, the suggested benefits of the added alpha-activity in patients with hypertension and angina remain to be proven by further trials in patients.

摘要
  1. 合并高血压和心绞痛的患者可能面临治疗困境，其心绞痛对传统β受体阻滞剂治疗无效。2. 硝苯地平可使外周血管扩张，有助于控制血压，这一额外益处已得到证实。3. 加用硝苯地平虽能更好地控制血压，但心绞痛的严重程度可能并未减轻，这凸显了此类患者心绞痛病因的复杂性。4. 拉贝洛尔具有临床证实的额外α受体阻滞活性，这使其有别于其他β受体阻滞剂。然而，拉贝洛尔额外的α受体阻滞活性对高血压合并心绞痛患者的潜在益处仍有待进一步临床试验证实。

相似文献

1
Alternatives to beta-blockade in therapy of hypertension with angina pectoris: role of nifedipine or of labetalol.硝苯地平或拉贝洛尔在伴有心绞痛的高血压治疗中作为β受体阻滞剂替代药物的作用
Br J Clin Pharmacol. 1982 Jun;13(1 Suppl):115S-122S. doi: 10.1111/j.1365-2125.1982.tb01899.x.
2
Open evaluation of labetalol in the treatment of angina pectoris occurring in hypertensive patients.拉贝洛尔治疗高血压患者心绞痛的开放性评估。
Br J Clin Pharmacol. 1979;8(Suppl 2):205S-209S.
3
Labetalol in hypertensive patients with angina pectoris: beneficial effect of combined alpha- and beta-adrenoreceptor blockade.
Clin Sci Mol Med Suppl. 1978 Dec;4:283s-286s. doi: 10.1042/cs055283s.
4
Labetalol therapy in patients with systemic hypertension and angina pectoris: effects of combined alpha and beta adrenoceptor blockade.拉贝洛尔治疗系统性高血压和心绞痛患者：α和β肾上腺素能受体联合阻滞的效果
Am J Cardiol. 1981 Nov;48(5):917-28. doi: 10.1016/0002-9149(81)90359-3.
5
Beneficial effect of labetalol in hypertensive patients with angina pectoris.
S Afr Med J. 1983 Jan 15;63(3):67-71.
6
Clinical pharmacology of the new beta-adrenergic blocking drugs. Part II. Effects of oral labetalol in patients with both angina pectoris and hypertension: a preliminary experience.
Am Heart J. 1980 Mar;99(3):388-96. doi: 10.1016/0002-8703(80)90354-3.
7
Double-blind trial comparing labetalol with atenolol in the treatment of systemic hypertension with angina pectoris.
Am J Cardiol. 1985 Sep 15;56(8):551-4. doi: 10.1016/0002-9149(85)91183-x.
8
The value of combined alpha- and beta-adrenoceptor blockade in angina pectoris.α和β肾上腺素能受体联合阻滞在心绞痛中的价值。
Postgrad Med J. 1983;59 Suppl 3:33-4.
9
Labetalol in the treatment of stable exertional angina pectoris: a comparison with nifedipine.拉贝洛尔治疗稳定型劳力性心绞痛：与硝苯地平的比较。
Eur Heart J. 1988 Nov;9(11):1200-5. doi: 10.1093/oxfordjournals.eurheartj.a062430.
10
Labetalol, an alpha- and beta-adrenoceptor-blocking agent: its use in therapeutics. A summary of the symposium.拉贝洛尔，一种α和β肾上腺素能受体阻滞剂：其在治疗中的应用。研讨会综述。
Br J Clin Pharmacol. 1979;8(Suppl 2):239S-244S.

引用本文的文献

1
Labetalol: the nineteen-eighties.拉贝洛尔：20世纪80年代。
Br J Clin Pharmacol. 1982 Jun;13(1 Suppl):137S-141S. doi: 10.1111/j.1365-2125.1982.tb01903.x.
2
Labetalol in normotensive patients with angina pectoris.拉贝洛尔用于患心绞痛的血压正常患者。
Cardiovasc Drugs Ther. 1988 Sep;2(3):363-7. doi: 10.1007/BF00054644.
3
Nifedipine. A review of its pharmacodynamic and pharmacokinetic properties, and therapeutic efficacy, in ischaemic heart disease, hypertension and related cardiovascular disorders.硝苯地平。对其在缺血性心脏病、高血压及相关心血管疾病中的药效学、药代动力学特性及治疗效果的综述。
Drugs. 1985 Sep;30(3):182-274. doi: 10.2165/00003495-198530030-00002.

本文引用的文献

1
Adverse interaction between nifedipine and beta-blockade.硝苯地平与β受体阻滞剂之间的不良相互作用。
Br Med J. 1980 Nov 29;281(6253):1462. doi: 10.1136/bmj.281.6253.1462.
2
Evidence for emotionally-induced coronary arterial spasm in patients with angina pectoris.心绞痛患者情绪诱发冠状动脉痉挛的证据。
Br Heart J. 1980 Jul;44(1):62-6. doi: 10.1136/hrt.44.1.62.
3
The developing phase of primary hypertension. II. Treatment.原发性高血压的发展阶段。II. 治疗。
Mod Concepts Cardiovasc Dis. 1980 May;49(5):25-30.
4
Objective assessment of antianginal treatment: a double-blind comparison of propranolol, nifedipine, and their combination.抗心绞痛治疗的客观评估：普萘洛尔、硝苯地平及其联合用药的双盲比较。
Br Med J. 1980 Jul 19;281(6234):184-7. doi: 10.1136/bmj.281.6234.184.
5
Nifedipine and beta-blocker drugs.硝苯地平和β受体阻滞剂药物。
Br Med J. 1980 Nov 8;281(6250):1251-2. doi: 10.1136/bmj.281.6250.1251-a.
6
Mortality and coronary heart disease among men studied for 23 years.
Arch Intern Med. 1971 Aug;128(2):201-214. doi: 10.1001/archinte.1971.00310200037002.
7
Blood-pressure and catecholamine excretion after mental stress in labile hypertension.
Lancet. 1969 Apr 5;1(7597):692-4. doi: 10.1016/s0140-6736(69)92645-2.
8
Simultaneous assessment of effects of coronary vasodilators on the coronary blood flow and the myocardial contractility by using the blood-perfused canine papillary muscle.通过使用血液灌注的犬乳头肌同时评估冠状动脉扩张剂对冠状动脉血流量和心肌收缩力的影响。
Jpn J Pharmacol. 1976 Aug;26(4):427-35. doi: 10.1254/jjp.26.427.
9
Differences in the mechanisms of borderline and permanent hypertension.临界高血压和持续性高血压机制的差异。
Postgrad Med J. 1977;53 Suppl 3:35-9.
10
Effect of blood pressure angiotensin II and aldosterone concentrations during treatment of severe hypertension with intravenous labetalol: comparison with propranolol.静脉注射拉贝洛尔治疗重度高血压期间血压、血管紧张素II及醛固酮浓度的变化：与普萘洛尔的比较
Br J Clin Pharmacol. 1976 Aug;3(4 Suppl 3):799-803.