Dady P J, McElwain T J, Austin D E, Barrett A, Peckham M J
Br J Cancer. 1982 Jun;45(6):851-9. doi: 10.1038/bjc.1982.137.
Since 1975, 191 patients with Hodgkin's disease have been treated with a combination of chlorambucil, vinblastine, procarbazine and prednisolone (ChlVPP). Complete remission rates were 73% for previously untreated patients, 91% for patients previously treated with radiotherapy and 55% for patients previously treated with chemotherapy. In 59 patients with advanced disease who received no other treatment, a 5-year survival rate of 66% was comparable with that achieved by more toxic mustine-containing combinations. ChlVPP has few side effects, is easily given to outpatients, and can be combined with elective radiotherapy in selected patients.
自1975年以来,191例霍奇金病患者接受了苯丁酸氮芥、长春花碱、丙卡巴肼和泼尼松(ChlVPP)联合治疗。初治患者的完全缓解率为73%,既往接受过放疗的患者为91%,既往接受过化疗的患者为55%。在59例未接受其他治疗的晚期疾病患者中,66%的5年生存率与使用毒性更强的含氮芥联合方案所取得的生存率相当。ChlVPP副作用少,易于门诊给药,并且在部分患者中可与选择性放疗联合使用。