Connellan S J, Gough S E
Br J Dis Chest. 1982 Apr;76(2):135-42.
The effects of 10 mg of nebulized salbutamol on lung mechanics and exercise tolerance in 10 patients with severe airflow obstruction are described. All patients were previously considered to have irreversible airflow obstruction as demonstrated by little or no improvement in expiratory flow rates either during a corticosteroid trial or after inhalation of 100 micrograms of isoprenaline. There was a small improvement in expiratory flow rate after nebulized salbutamol but the greatest increases were seen in slow vital capacity, inspiratory capacity, inspiratory flow rates, dynamic compliance during tidal breathing, mid-inspiratory and expiratory pulmonary resistance and exercise tolerance. The mechanism of these effects and their therapeutic significance is discussed.
本文描述了10例严重气流阻塞患者吸入10毫克雾化沙丁胺醇后对肺力学和运动耐力的影响。所有患者之前均被认为存在不可逆气流阻塞，这在皮质类固醇试验期间或吸入100微克异丙肾上腺素后呼气流量改善甚微或无改善中得到证实。雾化沙丁胺醇后呼气流量有小幅改善，但最大增幅出现在慢肺活量、吸气量、吸气流量、潮式呼吸时的动态顺应性、吸气中期和呼气期肺阻力以及运动耐力方面。文中讨论了这些效应的机制及其治疗意义。
