Corris P A, Neville E, Nariman S, Gibson G J
Thorax. 1983 Apr;38(4):292-6. doi: 10.1136/thx.38.4.292.
Dose-response relationships for salbutamol were studied in eight patients suffering from chronic airflow obstruction with no asthmatic features. Each inhaled, double blind, in randomised order 0, 200, 400, 800, and 1600 micrograms salbutamol on five successive mornings. Before and at intervals up to six hours after the inhalation FEV1, vital capacity, maximum inspiratory and expiratory flow-volume curves, and 12-minute walking distances were measured. Analysis of variance of the results indicated significant dose-response relationships and showed the larger doses to have a longer duration of action. Simple spirometric tests were as useful in providing objective evidence of benefit as maximum inspiratory flows or the 12-minute walking distance.
对8名无哮喘特征的慢性气流阻塞患者研究了沙丁胺醇的剂量反应关系。每位患者在连续五个早晨以随机顺序双盲吸入0、200、400、800和1600微克沙丁胺醇。在吸入前及吸入后长达6小时的间隔时间测量第一秒用力呼气容积（FEV1）、肺活量、最大吸气和呼气流量-容积曲线以及12分钟步行距离。结果的方差分析表明存在显著的剂量反应关系，并显示较大剂量有更长的作用持续时间。简单的肺量计测试在提供获益的客观证据方面与最大吸气流量或12分钟步行距离同样有用。
