• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

耳聋小鼠中枢听觉功能的保存

Preservation of central auditory function in the deafness mouse.

作者信息

Bock G R, Frank M P, Steel K P

出版信息

Brain Res. 1982 May 13;239(2):608-12. doi: 10.1016/0006-8993(82)90536-4.

DOI:10.1016/0006-8993(82)90536-4
PMID:7093705
Abstract

Deafness mice are profoundly deaf from birth as a result of genetically determined cochlear dysfunction. Evoked potentials in response to direct electrical stimulation of the cochlear nerve can readily be recorded in the inferior colliculus of deafness mice, and such responses are larger in amplitude than those in control mice. These observations indicate that at least some central connections become functional in the deafness central auditory pathway in the absence of peripheral stimulation, and are relevant to the general problem of restoring function by direct nerve stimulation in the profoundly deaf.

摘要

耳聋小鼠由于基因决定的耳蜗功能障碍,从出生起就严重失聪。在耳聋小鼠的下丘中,可以很容易地记录到对耳蜗神经直接电刺激的诱发电位,并且这种反应的幅度比对照小鼠中的反应幅度更大。这些观察结果表明,在没有外周刺激的情况下,至少一些中枢连接在耳聋的中枢听觉通路中变得具有功能,并且与在极重度耳聋中通过直接神经刺激恢复功能的一般问题相关。

相似文献

1
Preservation of central auditory function in the deafness mouse.耳聋小鼠中枢听觉功能的保存
Brain Res. 1982 May 13;239(2):608-12. doi: 10.1016/0006-8993(82)90536-4.
2
Auditory brain stem responses in the cat. II. Effects of lesions.猫的听觉脑干反应。II. 损伤的影响。
Electroencephalogr Clin Neurophysiol. 1980 Feb;48(2):174-90. doi: 10.1016/0013-4694(80)90302-8.
3
Electrical stimulation of the cochlear nerve in deafness mice.
Arch Otolaryngol. 1983 Aug;109(8):526-9. doi: 10.1001/archotol.1983.00800220032008.
4
Passive stimulation and behavioral training differentially transform temporal processing in the inferior colliculus and primary auditory cortex.被动刺激和行为训练以不同方式改变下丘和初级听觉皮层的时间处理。
J Neurophysiol. 2017 Jan 1;117(1):47-64. doi: 10.1152/jn.00392.2016. Epub 2016 Oct 12.
5
[Certain characteristics of on- and off-responses in the auditory system].[听觉系统中开反应和关反应的某些特征]
Fiziol Zh SSSR Im I M Sechenova. 1979 Jul;65(7):953-8.
6
Far-field acoustic response: origins in the cat.远场声学响应:猫的起源
Science. 1975 Aug 1;189(4200):382-4. doi: 10.1126/science.1145206.
7
The development of stimulus following in the cochlear nerve and inferior colliculus of the mouse.小鼠耳蜗神经和下丘中刺激跟随现象的发展
Brain Res. 1985 Oct;354(2):255-67. doi: 10.1016/0165-3806(85)90177-4.
8
Electrical cochlear stimulation in the deaf cat: comparisons between psychophysical and central auditory neuronal thresholds.聋猫的电耳蜗刺激:心理物理学阈值与中枢听觉神经元阈值的比较
J Neurophysiol. 2000 Apr;83(4):2145-62. doi: 10.1152/jn.2000.83.4.2145.
9
Auditory fatigue: retrocochlear components.
Science. 1975 Oct 31;190(4213):486-7. doi: 10.1126/science.1166320.
10
Stimulation by cochlear implant in unilaterally deaf rats reverses the decrease of inhibitory transmission in the inferior colliculus.人工耳蜗刺激单侧耳聋大鼠可逆转下丘抑制性突触传递的减少。
Eur J Neurosci. 2008 Oct;28(8):1589-602. doi: 10.1111/j.1460-9568.2008.06454.x.

引用本文的文献

1
Lateral superior olive function in congenital deafness.先天性耳聋中的外侧上橄榄核功能。
Hear Res. 2011 Jul;277(1-2):163-75. doi: 10.1016/j.heares.2011.01.012. Epub 2011 Jan 27.
2
Tmc1 is necessary for normal functional maturation and survival of inner and outer hair cells in the mouse cochlea.Tmc1对于小鼠耳蜗内、外毛细胞的正常功能成熟和存活是必需的。
J Physiol. 2006 Aug 1;574(Pt 3):677-98. doi: 10.1113/jphysiol.2005.095661. Epub 2006 Apr 20.
3
Activity-dependent regulation of synaptic strength and neuronal excitability in central auditory pathways.
中枢听觉通路中突触强度和神经元兴奋性的活动依赖性调节。
J Physiol. 2006 Apr 15;572(Pt 2):313-21. doi: 10.1113/jphysiol.2006.104851. Epub 2006 Feb 9.
4
Topographic organization in the auditory brainstem of juvenile mice is disrupted in congenital deafness.先天性耳聋会破坏幼年小鼠听觉脑干中的拓扑组织。
J Physiol. 2006 Mar 15;571(Pt 3):563-78. doi: 10.1113/jphysiol.2005.098780. Epub 2005 Dec 22.
5
Non-random nature of spontaneous mIPSCs in mouse auditory brainstem neurons revealed by recurrence quantification analysis.递归定量分析揭示小鼠听觉脑干神经元中自发性微小抑制性突触后电流的非随机性质
Proc Biol Sci. 2005 Dec 7;272(1580):2551-9. doi: 10.1098/rspb.2005.3258.
6
Auditory-nerve rate responses are inconsistent with common hypotheses for the neural correlates of loudness recruitment.听觉神经速率反应与响度重振的神经关联的常见假设不一致。
J Assoc Res Otolaryngol. 2005 Jun;6(2):91-105. doi: 10.1007/s10162-004-5043-0. Epub 2005 Jun 10.
7
Reduced low-voltage activated K+ conductances and enhanced central excitability in a congenitally deaf (dn/dn) mouse.先天性耳聋(dn/dn)小鼠中低电压激活的钾离子电导降低及中枢兴奋性增强
J Physiol. 2004 Aug 15;559(Pt 1):25-33. doi: 10.1113/jphysiol.2004.067421. Epub 2004 Jul 2.
8
Synaptic transmission in the auditory brainstem of normal and congenitally deaf mice.正常和先天性耳聋小鼠听觉脑干中的突触传递
J Physiol. 2002 Apr 15;540(Pt 2):447-55. doi: 10.1113/jphysiol.2001.013821.