Sanes D H, Constantine-Paton M
Brain Res. 1985 Oct;354(2):255-67. doi: 10.1016/0165-3806(85)90177-4.
The decrement of evoked response amplitudes during the presentation of repetitive clicks was examined quantitatively at the level of the eighth nerve and inferior colliculus in mice aged 13-60 days postnatal. The amplitudes of both these potentials were found to decline during the course of stimulation, this being much more severe at the onset of hearing than in adults. Furthermore the following response at the level of the cochlear nerve was adult-like by day 18, while the response at the level of the inferior colliculus continued to improve through day 24. Recordings in the inferior colliculus were consistently obtained in two different regions along the frequency axis. The regions that responded best to a lower range of frequencies (e.g. 3-9 kHz) showed a more rapid and severe decrement in the evoked response to repetitive stimulation than those regions responding best to a higher range of frequencies (e.g. 8-17 kHz). This was found to be the case for repetitive click stimuli and repetitive tone bursts. Single unit responses in the inferior colliculus were consistent with this differential decline as a function of stimulus rate seen along the frequency axis.
在出生后13 - 60天的小鼠中，对重复点击声刺激过程中听神经和下丘水平诱发反应幅度的衰减进行了定量研究。发现这两种电位的幅度在刺激过程中均下降，在听力开始时这种下降比成年小鼠严重得多。此外，到第18天，耳蜗神经水平的后续反应类似成年小鼠，而下丘水平的反应在第24天前持续改善。在下丘沿频率轴的两个不同区域持续获得记录。对较低频率范围（如3 - 9千赫）反应最佳的区域，与对较高频率范围（如8 - 17千赫）反应最佳的区域相比，对重复刺激的诱发反应衰减更快、更严重。对于重复点击刺激和重复纯音爆发均是如此。下丘中的单个神经元反应与此沿频率轴随刺激率的差异衰减一致。
