Ishikawa K, Shibanoki S, Saito S, McGaugh J L
Brain Res. 1982 May 20;240(1):158-61. doi: 10.1016/0006-8993(82)90655-2.
The effect of 5 kW microwave irradiation on monoamine metabolism was investigated in dissected regions of rat brain. Concentrations of intracerebral monoamines and their metabolites were simultaneously determined by means of high performance liquid chromatography with electrochemical detection. The concentrations of noradrenaline, dopamine and 5-hydroxytryptamine were reduced by a 0.5 s irradiation in comparison with those of decapitated animals. When the duration of irradiation was prolonged by 1.5 s, on the other hand, the levels of monoamines were increased. The changes of metabolite concentrations were generally opposite direction for those of parent transmitters. These findings suggest that the microwave irradiation affects those concentrations and that a 1.5 s irradiation is recommended in order to completely inactivate the corresponding enzyme prior to the simultaneous determination of monoamines' related substances in dissected brain regions.
研究了5千瓦微波辐射对大鼠脑部分离区域单胺代谢的影响。采用高效液相色谱-电化学检测法同时测定脑内单胺及其代谢产物的浓度。与断头动物相比，0.5秒的辐射使去甲肾上腺素、多巴胺和5-羟色胺的浓度降低。另一方面，当辐射时间延长至1.5秒时，单胺水平升高。代谢产物浓度的变化与母体递质的变化方向通常相反。这些发现表明微波辐射会影响这些浓度，并且建议进行1.5秒的辐射，以便在同时测定分离脑区中单胺相关物质之前使相应的酶完全失活。
