Rastegar A, Ciesielski L, Simler S, Messripour M, Mandel P
Centre de Neurochimie due CNRS, Strasbourg, France.
Neurochem Res. 1993 Apr;18(4):471-7. doi: 10.1007/BF00967251.
The effect of castration on the levels of brain monoamines and their metabolites has been investigated in rats which became or did not become muricidal following long-term isolation. Fourteen brain areas were explored: olfactory bulbs (OB), olfactory tubercles (OT), septum (Se), striatum (Sr), amygdala (A), thalamus (Th), hypothalamus (Hy), hippocampus (Hi), superior colliculus (SC), inferior colliculus (IC), raphe (Ra), pons-medulla (PM), frontal cortex (FC), temporal cortex (TC) and parietal cortex (PC). Except in the raphe of non muricidal rats and in the striatum of muricidal animals, all other areas examined demonstrate some changes of monoamines neurotransmitter or their metabolites after castration. The strongest changes, always increases, were found in the thalamus. In several brain areas, the changes occurring after castration, differ quantitatively and qualitatively in muricidal and non-muricidal rats.
在长期隔离后变得或未变得具有杀鼠行为的大鼠中，研究了去势对脑单胺及其代谢物水平的影响。研究了14个脑区：嗅球（OB）、嗅结节（OT）、隔区（Se）、纹状体（Sr）、杏仁核（A）、丘脑（Th）、下丘脑（Hy）、海马体（Hi）、上丘（SC）、下丘（IC）、中缝核（Ra）、脑桥延髓（PM）、额叶皮质（FC）、颞叶皮质（TC）和顶叶皮质（PC）。除了未出现杀鼠行为的大鼠的中缝核和出现杀鼠行为的动物的纹状体，所有其他检查区域在去势后均显示出单胺神经递质或其代谢物的一些变化。变化最明显的，且始终是增加的，是在丘脑中发现的。在几个脑区中，去势后发生的变化在出现杀鼠行为和未出现杀鼠行为的大鼠中在数量和质量上有所不同。
