Hayakawa T, Zyo K
Brain Res. 1982 May 20;240(1):3-11. doi: 10.1016/0006-8993(82)90639-4.
The afferent fiber connections to the interpeduncular (IP) complex were demonstrated by the retrograde axonal transport of horseradish peroxidase (HRP) in cats. The HRP was injected into each nucleus of the IP complex, that is the central nucleus (IPC), the paramedian nucleus (IPP), the apical nucleus (IPA), and the posterior nucleus (IPN) including the outer division (IPO) and the inner division (IPI), and surrounding areas of the IP complex, using a ventral or dorsal surgical approaches. Most of the labeled neurons were in the medial habenular nucleus (MH) and each of the sub-nuclei of the IP complex was related to a specific part of the MH. Thus, the mediodorsal part of MH projected to the IPC, the medioventral part of MH projected to the IPI, the laterodorsal part of MH projected to the IPA, and the lateroventral part of MH projected to the IPP and the IPO. There were a few labeled cells in the accessory dorsal tegmental nucleus, the nucleus raphe dorsalis (RD), the nucleus centralis superior, the nucleus of the locus coeruleus, the gray matter of the floor of the fourth ventricle, and the nucleus of diagonal band of Broca, but there were no obvious patterns in the projections of these nuclei to the different sub-nuclei of the IP complex. When the area of the HRP injection involved the midbrain reticular formation adjacent to the IP complex and the nucleus reticularis tegmenti pontis (RT) but not the IP complex itself, there were many labeled cells in the lateral habenular nucleus and the medial and lateral mammillary nuclei, but there were no labeled cells in the medial habenular nucleus.
通过辣根过氧化物酶（HRP）逆行轴突运输法，在猫身上展示了传入纤维与脚间（IP）复合体的连接。采用腹侧或背侧手术入路，将HRP注入IP复合体的每个核团，即中央核（IPC）、正中旁核（IPP）、尖核（IPA）以及包括外侧部（IPO）和内侧部（IPI）的后核（IPN），还有IP复合体的周围区域。大多数标记神经元位于内侧缰核（MH），并且IP复合体的每个亚核都与MH的特定部分相关。因此，MH的中间背侧部分投射到IPC，MH的中间腹侧部分投射到IPI，MH的外侧背侧部分投射到IPA，MH的外侧腹侧部分投射到IPP和IPO。在背侧被盖副核、中缝背核（RD）、中央上核、蓝斑核、第四脑室底灰质以及布罗卡斜带核中有少数标记细胞，但这些核向IP复合体不同亚核的投射没有明显模式。当HRP注射区域涉及与IP复合体相邻的中脑网状结构和脑桥被盖网状核（RT），而不包括IP复合体本身时，外侧缰核以及内侧和外侧乳头核中有许多标记细胞，但内侧缰核中没有标记细胞。
