Velayos J L, Reinoso-Suarez F
J Comp Neurol. 1982 Mar 20;206(1):17-27. doi: 10.1002/cne.902060104.
The afferent projections from the brainstem to the mediodorsal thalamic nucleus (MD) were studied in the cat, by means of retrograde transport of horseradish peroxidase. A topographical arrangement of these projections is described. The medial part of MD is the area of the nucleus which receives fewer afferents from the brainstem. After injections in this part, labeled neurons were observed mainly in the interpeduncular nucleus, the ventral tegmental area and the substantia nigra. After injections of HRP in the intermediate part of the MD, labeled cells were seen mainly in the interpeduncular nucleus, substantia nigra, dorsal and centralis superior raphe nuclei, dorsal tegmental nucleus, and coeruleus complex. Less conspicuous was the number of labeled cells in the central gray and the dorsolateral portion of the tegmentum of the mesencephalon and pons. After injections in the lateral part of MD, labeled neurons were observed mainly in the deep layers of the superior colliculus, central gray, the oral paramedian pontine reticular tegmentum, and the interpeduncular nucleus. Labeled cells were also observed in the substantia nigra, locus coeruleus, dorsal tegmental nucleus, cuneiform area, and the mesencephalic reticular formation. These findings show the MD as a thalamic link of three different groups of brain-stem structures projecting to different cortical areas with different functional significance.
利用辣根过氧化物酶的逆行运输法，在猫身上研究了从脑干到丘脑背内侧核（MD）的传入投射。描述了这些投射的拓扑排列。MD的内侧部分是接受脑干传入纤维较少的核区。在此区域注射后，主要在脚间核、腹侧被盖区和黑质中观察到标记神经元。在MD中间部分注射HRP后，标记细胞主要见于脚间核、黑质、中缝背核和中缝中央核、背侧被盖核以及蓝斑复合体。中脑和脑桥被盖的中央灰质和背外侧部分的标记细胞数量较少。在MD外侧部分注射后，主要在上丘深层、中央灰质、脑桥旁正中网状被盖口区和脚间核中观察到标记神经元。在黑质、蓝斑、背侧被盖核、楔形区和中脑网状结构中也观察到标记细胞。这些发现表明，MD是投射到具有不同功能意义的不同皮质区域的三组不同脑干结构的丘脑连接。
