Weigand R A, Isenberg W M, Russo J, Brennan M J, Rich M A
Cancer. 1982 Sep 1;50(5):962-9. doi: 10.1002/1097-0142(19820901)50:5<962::aid-cncr2820500526>3.0.co;2-x.
Blood vessel invasion and axillary lymph node involvement were examined in 175 breast cancer patients. The incidence of blood vessel invasion was 35%. The presence of blood vessel invasion was highly associated with early disease recurrence. The association of poor prognosis with blood vessel invasion was independent of clinical stage, menopausal status, node status, tumor size, or postsurgical treatment. Those patients with blood vessel invasion and two or more positive nodes were at extremely high risk for early recurrence (70% recurrence by two years compared with 15% recurrence in the remainder of the patients). Thus, blood vessel invasion is a useful indicator of early recurrence in patients with primary breast cancer and, in combination with node status, is a prognostic indicator with high discriminatory power.
对175例乳腺癌患者进行了血管侵犯和腋窝淋巴结受累情况检查。血管侵犯的发生率为35%。血管侵犯的存在与疾病早期复发高度相关。血管侵犯与预后不良的关联独立于临床分期、绝经状态、淋巴结状态、肿瘤大小或术后治疗。那些有血管侵犯且两个或更多淋巴结阳性的患者早期复发风险极高（两年内复发率为70%，而其余患者的复发率为15%）。因此，血管侵犯是原发性乳腺癌患者早期复发的一个有用指标，并且与淋巴结状态相结合，是一个具有高鉴别力的预后指标。
