White P J, Hoch S O
Cancer Biochem Biophys. 1982;6(1):19-22.
High titers of C3DP, a DNA-binding derivative of complement C3, have been reported to occur in the sera of individuals with active malignant disease. The mechanism of generation of C3DP remained obscure. We report here that C3DP is not generated in vitro under the conditions required for its isolation and subsequent assay. However, under certain storage conditions, all sera (normal and malignant) produce C3DP. This severely limits the usefulness of the assay for diagnostic and prognostic purposes.
据报道，补体C3的一种DNA结合衍生物C3DP的高滴度存在于患有活动性恶性疾病的个体血清中。C3DP的产生机制仍不清楚。我们在此报告，在其分离及后续检测所需的条件下，C3DP无法在体外产生。然而，在某些储存条件下，所有血清（正常和恶性）都会产生C3DP。这严重限制了该检测在诊断和预后方面的用途。
