Ash S R, Thornhill J A, Dhein C R, Rebar A H
Clin Exp Dial Apheresis. 1982;6(1):25-44. doi: 10.3109/08860228209050811.
In canine veterinary medicine, both acute and chronic renal failure occur relatively frequently, from a variety of causes similar to those in man. However, the normal dog has a very high protein catabolic rate and high endogenous kidney function, and, therefore, requires frequent and highly efficient dialysis, for maintenance during renal failure. We have developed techniques to support the uremic dog with hemodialysis. An experimentally anephric dog, and two dogs with clinically occurring acute renal failure (caused by ethylene glycol intoxication and heat stroke) have been supported with frequent use of hollow fiber dialyzers, using a carotid artery to jugular vein shunt. Patency of shunts was maintained by administration of oral aspirin. A very high urea and creatinine generation rate necessitated daily dialysis during much of the clinical course of renal failure. The experimentally anuric animal was supported for 35 days. The ethylene glycol-induced renal failure animal was euthanized on the 21st day, and the heat stress-induced renal failure animal recovered sufficient intrinsic renal function after 16 days of dialysis for maintenance of life without dialysis.
在犬类兽医学中，急性和慢性肾衰竭相对频繁地发生，其病因与人类的多种病因相似。然而，正常犬类具有非常高的蛋白质分解代谢率和较高的内源性肾功能，因此，在肾衰竭期间需要频繁且高效的透析来维持生命。我们已经开发出了用血液透析支持尿毒症犬的技术。一只实验性无肾犬以及两只临床上发生急性肾衰竭（由乙二醇中毒和中暑引起）的犬，通过频繁使用中空纤维透析器，并利用颈动脉至颈静脉分流术，得到了支持治疗。通过口服阿司匹林维持分流的通畅。在肾衰竭的大部分临床病程中，极高的尿素和肌酐生成率使得每天都需要进行透析。实验性无尿动物维持了35天。乙二醇诱导的肾衰竭动物在第21天实施了安乐死，而热应激诱导的肾衰竭动物在透析16天后恢复了足够的固有肾功能，无需透析即可维持生命。
