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Liposomes (multilamellar vesicles, MLV) were prepared which entrapped triiodothyronine (T3). The MLV were composed of dimyristoylphosphatidylcholine, cholesterol and dicetylphosphate as DMPC alone, DMPC:Chol (7.2 molar ratio) and DMPC:Chol:DCP (7:2:1 molar ratio). 2. The optimal T3 entrapment was within MLV composed of DMPC: Chol:DCP. The entrapped concentrations of T3 was 63.1%. 3. The MLV composed of DMPC:Chol:DCP did not leak T3 from the MLV into buffered saline but did leak T3 into serum (42.5% after 4 h). 4. The MLV composed of DMPC:Chol:DCP exhibited a distribution of T3 between membrane associated and membrane entrapped of 42.58%.

制备了包封三碘甲状腺原氨酸（T3）的脂质体（多层囊泡，MLV）。MLV由二肉豆蔻酰磷脂酰胆碱、胆固醇和十六烷基磷酸酯组成，分别为单独的二肉豆蔻酰磷脂酰胆碱、二肉豆蔻酰磷脂酰胆碱：胆固醇（摩尔比7.2）和二肉豆蔻酰磷脂酰胆碱：胆固醇：十六烷基磷酸酯（摩尔比7:2:1）。2. 最佳的T3包封率出现在由二肉豆蔻酰磷脂酰胆碱：胆固醇：十六烷基磷酸酯组成的MLV中。T3的包封浓度为63.1%。3. 由二肉豆蔻酰磷脂酰胆碱：胆固醇：十六烷基磷酸酯组成的MLV不会将T3从MLV泄漏到缓冲盐溶液中，但会将T3泄漏到血清中（4小时后为42.5%）。4. 由二肉豆蔻酰磷脂酰胆碱：胆固醇：十六烷基磷酸酯组成的MLV在膜结合和膜包封的T3之间的分布为42.58%。

Liposomes (multilamellar vesicles, MLV) were prepared which entrapped triiodothyronine (T3). The MLV were composed of dimyristoylphosphatidylcholine, cholesterol and dicetylphosphate as DMPC alone, DMPC:Chol (7.2 molar ratio) and DMPC:Chol:DCP (7:2:1 molar ratio). 2. The optimal T3 entrapment was within MLV composed of DMPC: Chol:DCP. The entrapped concentrations of T3 was 63.1%. 3. The MLV composed of DMPC:Chol:DCP did not leak T3 from the MLV into buffered saline but did leak T3 into serum (42.5% after 4 h). 4. The MLV composed of DMPC:Chol:DCP exhibited a distribution of T3 between membrane associated and membrane entrapped of 42.58%.

制备了包封三碘甲状腺原氨酸（T3）的脂质体（多层囊泡，MLV）。MLV由二肉豆蔻酰磷脂酰胆碱、胆固醇和十六烷基磷酸酯组成，分别为单独的二肉豆蔻酰磷脂酰胆碱、二肉豆蔻酰磷脂酰胆碱：胆固醇（摩尔比7.2）和二肉豆蔻酰磷脂酰胆碱：胆固醇：十六烷基磷酸酯（摩尔比7:2:1）。2. 最佳的T3包封率出现在由二肉豆蔻酰磷脂酰胆碱：胆固醇：十六烷基磷酸酯组成的MLV中。T3的包封浓度为63.1%。3. 由二肉豆蔻酰磷脂酰胆碱：胆固醇：十六烷基磷酸酯组成的MLV不会将T3从MLV泄漏到缓冲盐溶液中，但会将T3泄漏到血清中（4小时后为42.5%）。4. 由二肉豆蔻酰磷脂酰胆碱：胆固醇：十六烷基磷酸酯组成的MLV在膜结合和膜包封的T3之间的分布为42.58%。

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