Gray G R, Marion R B
Can Med Assoc J. 1978 Oct 7;119(7):701-4.
A number of varieties of thalassemia were found to be common in the Vancouver area and in other parts of British Columbia. Of 3117 patients whose blood samples were studied by hemoglobin electrophoresis at the Vancouver General Hospital between Jan 1, 1965 and June 30,1977, 813 had the beta-thalassemia trait, 18 had homozygous beta-thalassemia, 97 had alpha-thalassemia trait, 24 had hemoglobin H disease and 14 had miscellaneous variants. Eight patients had interactions of beta-thalassemia with hemoglobin S,C, D, O arab or Vancouver, and one patient had alpha thalassemia associated with hemoglobin Constant Spring. Twelve other variants were noted. They included hemoglobins B2, E, Q, GHsi Tsou, J Bangkok, British Columbia, KOLN, Lepore, Rampa, Tacoma, St. Claude and an unidentified alpha-chain variant.
研究发现，多种类型的地中海贫血在温哥华地区和不列颠哥伦比亚省的其他地方很常见。在1965年1月1日至1977年6月30日期间，温哥华总医院对3117名患者的血样进行了血红蛋白电泳研究，其中813人有β地中海贫血特征，18人患有纯合子β地中海贫血，97人有α地中海贫血特征，24人患有血红蛋白H病，14人有其他变异类型。8名患者的β地中海贫血与血红蛋白S、C、D、O阿拉伯型或温哥华型相互作用，1名患者的α地中海贫血与血红蛋白恒河猴型相关。还发现了其他12种变异类型。它们包括血红蛋白B2、E、Q、GHsi Tsou、J曼谷、不列颠哥伦比亚、科隆、 Lepore、Rampa、塔科马、圣克劳德以及一种未鉴定的α链变异型。
