Gray G R, Marion R B
Can Med Assoc J. 1971 Aug 7;105(3):283-6.
Admission screening was performed on 684 Chinese-Canadian patients for thalassemia, abnormal hemoglobins and glucose-6-phosphate dehydrogenase (G-6-PD) deficiency. Thirty-six healthy Chinese adults were also studied. The incidence of beta-thalassemia minor (hemoglobin A(2) greater than 3.5%) was 3.8%. Presumptive alpha-thalassemia minor (demonstration of occasional red cells containing hemoglobin H inclusion bodies) was found in 6.7%. Two patients had findings consistent with alpha-beta-thalassemia. The incidence of G-6-PD deficiency (abnormal methemoglobin reduction test) in adult males was 4.7%. In a parallel study the incidence of hemoglobin Bart's in 310 Chinese newborns was 6.8%. Two mutant hemoglobins were found - hemoglobin E and hemoglobin J (Bangkok).
对684名华裔加拿大患者进行了地中海贫血、异常血红蛋白和葡萄糖-6-磷酸脱氢酶（G-6-PD）缺乏症的入院筛查。还对36名健康的中国成年人进行了研究。轻度β地中海贫血（血红蛋白A2大于3.5%）的发病率为3.8%。推测的轻度α地中海贫血（偶尔发现含有血红蛋白H包涵体的红细胞）的发生率为6.7%。两名患者的检查结果与α-β地中海贫血一致。成年男性中G-6-PD缺乏症（高铁血红蛋白还原试验异常）的发生率为4.7%。在一项平行研究中，310名中国新生儿中血红蛋白Bart's的发生率为6.8%。发现了两种突变血红蛋白——血红蛋白E和血红蛋白J（曼谷型）。
