Linssen A, Tytgat G N
Dig Dis Sci. 1982 Aug;27(8):731-6. doi: 10.1007/BF01393770.
Six female patients are described with a fulminant onset of Crohn's's disease involving the whole of the colon. The initial picture resembled that of an acute infectious diarrhea, but rapid clinical deterioration with pronounced weight loss, major anal complications, toxic megacolon, and erythema nodosum necessitated reappraisal of the diagnosis. Extensive endoscopy and multiple biopsies confirmed the diagnosis of pancolitis in all patients. Only one patient needed resection. Recognition of such fulminant onset as a distinct clinical modality in Crohn disease of the colon and starting treatment immediately upon diagnosis is probably important in preventing the development of a critical clinical situation.
本文描述了6例女性患者，她们均以暴发性克罗恩病起病，累及整个结肠。初始表现类似急性感染性腹泻，但迅速出现临床恶化，伴有明显体重减轻、严重肛门并发症、中毒性巨结肠和结节性红斑，这使得有必要重新评估诊断。广泛的内镜检查和多次活检证实所有患者均为全结肠炎。仅1例患者需要进行手术切除。认识到这种暴发性起病是结肠克罗恩病的一种独特临床类型，并在诊断后立即开始治疗，对于预防严重临床情况的发生可能很重要。
