Heimann G, Murgescu J, Bergt U
Eur J Clin Pharmacol. 1982;22(2):171-3. doi: 10.1007/BF00542463.
16 premature infants suffering from neonatal apnoea received orally an aqueous solution of theophylline 5 mg/kg bodyweight under fasting conditions and immediately before a milk feed. Bioavailability up to 7 h after administration was determined from the serum concentration-time course. The rate of absorption was significantly decreased if the drug was given with food; mean maximum serum concentrations were reached after 4.7 h instead of 1.6 h under fasting conditions. The area under the curve did not differ between the two patient groups which indicates that only the rate but not the amount of absorption was affected by food intake. The influence of feeding on the rate of absorption of theophylline by premature infants, which is more pronounced than in adults, can be related to particular functional factors in the gastrointestinal tract during the neonatal period.
16名患有新生儿呼吸暂停的早产儿在禁食条件下且在喂奶前立即口服了5毫克/千克体重的茶碱水溶液。根据血清浓度-时间过程确定给药后长达7小时的生物利用度。如果药物与食物一起服用，吸收速率会显著降低；在禁食条件下，平均最大血清浓度在4.7小时后达到，而不是1.6小时。两组患者的曲线下面积没有差异，这表明食物摄入仅影响吸收速率，而不影响吸收量。喂食对早产儿茶碱吸收速率的影响比成年人更明显，这可能与新生儿期胃肠道的特定功能因素有关。
