Reese J, Prentice G, Yu V Y
Monash Medical Centre, Clayton, Victoria, Australia.
Arch Dis Child Fetal Neonatal Ed. 1994 Jul;71(1):F51-2. doi: 10.1136/fn.71.1.f51.
Twenty two preterm infants were prospectively evaluated to assess the need for dose adjustment when converting enteral and parenteral routes of methylxanthine administration.Serum theophylline concentrations remained unchanged in 18 infants after conversion from intravenous aminophylline to theophylline by mouth without dose reduction, as is currently recommended [corrected]. Intravenous aminophylline and theophylline by mouth may therefore be prescribed at equivalent doses, with a possible reduction in drug errors, and improved stability of serum concentrations.
对22名早产儿进行前瞻性评估，以确定在转换甲基黄嘌呤的肠内和肠外给药途径时是否需要调整剂量。按照目前推荐的方法，18名婴儿从静脉注射氨茶碱转换为口服茶碱后，血清茶碱浓度在未降低剂量的情况下保持不变[已修正]。因此，静脉注射氨茶碱和口服茶碱可以采用等效剂量给药，这可能会减少用药错误，并提高血清浓度的稳定性。
