Rubegni M, Sacchetti G, Bruni G, De Mauro G, Bandinelli C, Provvedi D
J Int Med Res. 1982;10(3):189-93. doi: 10.1177/030006058201000309.
The influence of i.v. administration of indoprofen on template bleeding time and other haemostatic parameters was investigated in ten elderly subjects with osteoarthritis. The drug was given first as a single dose (400 mg bolus) and then, after an appropriate interval, as a short-term treatment (200 mg bolus t.i.d. for 7 days). Platelet count, prothrombin time and partial thromboplastin time were never affected, whereas a significant, though moderate, lengthening of bleeding time and a parallel reduction of platelet aggregation were observed in both trials. In the acute one these changes were seen at the first hour following administration and waned in all patients within 96 hours. In the subacute test the bleeding time was steadily prolonged throughout the week of treatment, being slightly still above the baseline value 7 days later, at which time no residual effects were noticeable in platelet aggregation.
在10名患骨关节炎的老年受试者中，研究了静脉注射吲哚美辛对模板出血时间和其他止血参数的影响。首先给予单剂量药物（400mg推注），然后在适当间隔后，进行短期治疗（200mg推注，每日3次，共7天）。血小板计数、凝血酶原时间和部分凝血活酶时间从未受到影响，而在两项试验中均观察到出血时间显著但适度延长，同时血小板聚集平行减少。在急性试验中，这些变化在给药后的第一小时出现，并在所有患者中于96小时内消退。在亚急性试验中，出血时间在整个治疗周内持续延长，7天后仍略高于基线值，此时血小板聚集无明显残留效应。
