Underwood J W, Adcock L L, Okagaki T
Cancer. 1978 Oct;42(4):1851-8. doi: 10.1002/1097-0142(197810)42:4<1851::aid-cncr2820420424>3.0.co;2-2.
History and clinical findings of 18 cases of adenosquamous carcinoma of the skin appendages found among 135 cases of primary carcinoma of the vulva seen at the University of Minnesota Hospital between 1951 and 1970 were analyzed. In addition, two recent cases of this tumor were studied with conventional transmission electron microscopy. Adenosquamous carcinoma of the vulva showed poorer survival and a higher rate of lymph node metastases than squamous cell carcinoma of the corresponding stages (carcinoma in situ excluded). In four out of thirteen cases, the metastatic lesions in the lymph nodes retained glandular pattern. The ultrastructure showed mucin-producing columnar cells lining glandular lumina, and poorly differentiated squamous cells elsewhere; further, cells of the intermediate type between the two were present. This study indicates that adenosquamous carcinoma of the vulva is a distinctively separate entity from squamous cell carcinoma of the vulva, and possibly arises from mucin-producing cells of the skin appendages as suggested by Johnson and Helwig.
对1951年至1970年间在明尼苏达大学医院就诊的135例原发性外阴癌中发现的18例皮肤附属器腺鳞癌的病史和临床发现进行了分析。此外，用传统透射电子显微镜研究了该肿瘤的2例近期病例。外阴腺鳞癌与相应分期（原位癌除外）的鳞状细胞癌相比，生存率较低，淋巴结转移率较高。在13例病例中的4例中，淋巴结转移灶保留腺管结构。超微结构显示腺管腔内衬有产生黏液的柱状细胞，其他部位为低分化鳞状细胞；此外，还存在介于两者之间的中间型细胞。本研究表明，外阴腺鳞癌是一种与外阴鳞状细胞癌明显不同的实体，可能如约翰逊和赫尔维格所提示的那样，起源于皮肤附属器的产生黏液的细胞。
