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对晚期癌症患者进行瘤内、淋巴结内、静脉内和腹腔内注射短小棒状杆菌治疗的初步研究。

A preliminary study of intralesional, intralymph node, intravenous and intraperitoneal Corynebacterium parvum treatments in patients with advanced cancer.

作者信息

Cheng V S, Suit H D, Wang C C, Raker J, Weymuller E, Kaufman S

出版信息

Cancer. 1978 Oct;42(4):1912-5. doi: 10.1002/1097-0142(197810)42:4<1912::aid-cncr2820420432>3.0.co;2-5.

DOI:10.1002/1097-0142(197810)42:4<1912::aid-cncr2820420432>3.0.co;2-5
PMID:709538
Abstract

Twenty-one patients with squamous cell carcinoma of oral cavity and/or cervical lymph node and four patients with soft tissue sarcomas were given intralesional (2-4 mg/m2) and intralymph node (2-4 mg/m2) C. parvum injections followed by 5 intravenous (2-4 mg/m2) C. parvum treatments and conventional therapies. Seven patients with Stage III ovarian carcinomas were given intraperitoneal (2-4 mg/m2) C. parvum injections followed by conventional therapies. The local and systemic effects of the C. parvum treatments were described and the anti-tumor effects were evaluated in this series of patients.

摘要

21例口腔鳞状细胞癌和/或颈部淋巴结癌患者以及4例软组织肉瘤患者接受了瘤内(2 - 4mg/m²)和淋巴结内(2 - 4mg/m²)注射微小隐孢子虫,随后进行5次静脉注射(2 - 4mg/m²)微小隐孢子虫治疗及常规治疗。7例III期卵巢癌患者接受了腹腔内(2 - 4mg/m²)注射微小隐孢子虫,随后进行常规治疗。描述了微小隐孢子虫治疗的局部和全身效应,并对这一系列患者的抗肿瘤效果进行了评估。

相似文献

1
A preliminary study of intralesional, intralymph node, intravenous and intraperitoneal Corynebacterium parvum treatments in patients with advanced cancer.对晚期癌症患者进行瘤内、淋巴结内、静脉内和腹腔内注射短小棒状杆菌治疗的初步研究。
Cancer. 1978 Oct;42(4):1912-5. doi: 10.1002/1097-0142(197810)42:4<1912::aid-cncr2820420432>3.0.co;2-5.
2
Clinical trial of Corynebacterium parvum (intra-lymph-node and intravenous) and radiation therapy in the treatment of head and neck carcinoma.短小棒状杆菌(淋巴结内及静脉内注射)与放射治疗联合用于头颈部癌治疗的临床试验
Cancer. 1982 Jan 15;49(2):239-44. doi: 10.1002/1097-0142(19820115)49:2<239::aid-cncr2820490208>3.0.co;2-#.
3
Adjuvant intralesional and systemic Corynebacterium parvum immunotherapy for surgically treated head and neck cancer.辅助性瘤内及全身性短小棒状杆菌免疫疗法用于手术治疗的头颈癌
Surg Forum. 1978;29:155-7.
4
Intraperitoneal immunotherapy of human ovarian carcinoma with Corynebacterium parvum.短小棒状杆菌对人卵巢癌的腹腔内免疫治疗
Cancer Res. 1983 Mar;43(3):1395-401.
5
Adjuvant Corynebacterium parvum immunotherapy for squamous cell epitheliomas of the oral cavity, pharynx, and larynx.口腔、咽及喉鳞状细胞上皮瘤的辅助短小棒状杆菌免疫疗法。
J Surg Oncol. 1985 Feb;28(2):137-45. doi: 10.1002/jso.2930280215.
6
Methotrexate alone or with regional subcutaneous Corynebacterium parvum in the treatment of recurrent and metastatic squamous cancer of the head and neck.甲氨蝶呤单独或联合局部皮下注射短小棒状杆菌治疗复发性和转移性头颈部鳞状细胞癌。
Cancer. 1982 Dec 1;50(11):2295-300. doi: 10.1002/1097-0142(19821201)50:11<2295::aid-cncr2820501113>3.0.co;2-4.
7
Phase III study on the treatment of women with cervical cancer, stage IIB, IIIB, and IVA (confined to the pelvis and/or periaortic nodes), with radiotherapy alone versus radiotherapy plus immunotherapy with intravenous Corynebacterium parvum: a Gynecologic Oncology Group Study.一项针对IIB期、IIIB期和IVA期(局限于盆腔和/或腹主动脉旁淋巴结)宫颈癌女性患者的III期研究:单纯放疗与放疗联合静脉注射微小棒状杆菌免疫疗法的对比——妇科肿瘤学组研究
Gynecol Oncol. 1987 Mar;26(3):386-97. doi: 10.1016/0090-8258(87)90031-x.
8
Effect of Corynebacterium parvum on tumor growth in the central nervous system of mice.短小棒状杆菌对小鼠中枢神经系统肿瘤生长的影响。
J Natl Cancer Inst. 1978 Sep;61(3):827-32.
9
Intravenous Corynebacterium parvum: an adjunct to chemotherapy for resistant advanced ovarian cancer.静脉注射短小棒状杆菌:耐药晚期卵巢癌化疗的辅助治疗手段
Cancer. 1977 Feb;39(2):514-26. doi: 10.1002/1097-0142(197702)39:2<514::aid-cncr2820390220>3.0.co;2-#.
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Failure of Corynebacterium parvum presensitization to modify the antitumor effects of systemic and local therapeutic injections of C. parvum in mice.微小棒状杆菌预先致敏未能改变全身和局部注射微小棒状杆菌对小鼠的抗肿瘤作用。
J Natl Cancer Inst. 1976 Mar;56(3):675-7. doi: 10.1093/jnci/56.3.675.

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Ultrasound-guided intra-tumoral administration of directly-injected therapies: a review of the technical and logistical considerations.超声引导下瘤内直接注射治疗:技术和后勤考虑因素的综述。
Cancer Imaging. 2024 Oct 25;24(1):145. doi: 10.1186/s40644-024-00763-y.
2
Addressing the Adult Soft Tissue Sarcoma Microenvironment with Intratumoral Immunotherapy.通过瘤内免疫疗法应对成人软组织肉瘤微环境
Sarcoma. 2018 Aug 12;2018:9305294. doi: 10.1155/2018/9305294. eCollection 2018.