真菌代谢产物的抗肿瘤活性：疣孢菌素β-9,10-环氧化物
Antitumor activity of fungal metabolites: verrucarin beta-9, 10-epoxides.
作者信息
Jarvis B B, Stahly G P, Curtis C R
出版信息
Cancer Treat Rep. 1978 Oct;62(10):1585-6.
PMID:709560
Abstract
Verrucarins A (4) and B (5) and verrucarin A acetate, in vivo antileukemic inactive fungal metabolites, have been oxidized with m-chloroperoxybenzoic acid to give verrucarin beta-9,10-epoxides which show high in vivo activity against P388 mouse leukemia.
摘要
疣孢菌素A（4）和B（5）以及疣孢菌素A醋酸酯，这些在体内无抗白血病活性的真菌代谢产物，已用间氯过氧苯甲酸进行氧化，得到疣孢菌素β-9,10-环氧化物，它们对P388小鼠白血病显示出高体内活性。
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