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12,13-环氧单端孢霉烯族毒素木霉醇、二醋酸藨草镰刀菌烯醇和疣孢漆斑菌毒素A对酿酒酵母蛋白质合成的抑制作用。作用的可逆性。

Inhibition of protein synthesis in Saccharomyces cerevisiae by the 12,13-epoxytrichothecenes trichodermol, diacetoxyscirpenol and verrucarin A. Reversibility of the effects.

作者信息

Hernández F, Cannon M

出版信息

J Antibiot (Tokyo). 1982 Jul;35(7):875-81. doi: 10.7164/antibiotics.35.875.

DOI:10.7164/antibiotics.35.875
PMID:6757231
Abstract

Inhibition of protein synthesis by trichodermol, diacetoxyscirpenol and verrucarin A in cells and spheroplasts of Saccharomyces cerevisiae was investigated. Inhibition was reversible for trichodermol and diacetoxyscirpenol, both drugs being removed from their target site(s) by washing, but was reversible for verrucarin A. These results are interpreted in relation to variations in chemical structure between these trichothecenes.

摘要

研究了曲霉菌醇、二乙酰氧基麦角甾醇和疣孢菌素A对酿酒酵母细胞和原生质球中蛋白质合成的抑制作用。曲霉菌醇和二乙酰氧基麦角甾醇的抑制作用是可逆的，通过洗涤可将这两种药物从其作用靶点去除，但疣孢菌素A的抑制作用不可逆。根据这些单端孢霉烯族毒素之间化学结构的差异对这些结果进行了解释。

相似文献

1
Inhibition of protein synthesis in Saccharomyces cerevisiae by the 12,13-epoxytrichothecenes trichodermol, diacetoxyscirpenol and verrucarin A. Reversibility of the effects.12,13-环氧单端孢霉烯族毒素木霉醇、二醋酸藨草镰刀菌烯醇和疣孢漆斑菌毒素A对酿酒酵母蛋白质合成的抑制作用。作用的可逆性。
J Antibiot (Tokyo). 1982 Jul;35(7):875-81. doi: 10.7164/antibiotics.35.875.
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Competition between trichodermin and several other sesquiterpene antibiotics for binding to their receptor site(s) on eukaryotic ribosomes.木霉菌素与其他几种倍半萜抗生素在真核生物核糖体上与其受体位点结合的竞争。
Biochem J. 1976 Nov 15;160(2):137-45. doi: 10.1042/bj1600137.
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Ribosomal resistance to the 12,13-epoxytrichothecene antibiotics in the producing organism Myrothecium verrucaria.产孢生物体疣孢漆斑菌中核糖体对12,13-环氧单端孢霉烯族毒素抗生素的抗性。
Biochem J. 1980 Sep 15;190(3):765-70. doi: 10.1042/bj1900765.
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Mechanism of action of the 12,13-epoxytrichothecene, anguidine, an inhibitor of protein synthesis.12,13-环氧单端孢霉烯族毒素安圭定（一种蛋白质合成抑制剂）的作用机制
Biochim Biophys Acta. 1976 Dec 1;454(2):273-84. doi: 10.1016/0005-2787(76)90230-6.
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Mapping of trichodermin resistance in Saccharomyces cerevisiae: a genetic locus for a component of the 60S ribsomal subunit.酿酒酵母中抗木霉菌素的定位：60S核糖体亚基一个组分的基因座
Genetics. 1976 Aug;83(4):667-73. doi: 10.1093/genetics/83.4.667.
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Cloning of yeast gene for trichodermin resistance and ribosomal protein L3.抗木霉菌素酵母基因与核糖体蛋白L3的克隆
Proc Natl Acad Sci U S A. 1981 Jan;78(1):238-42. doi: 10.1073/pnas.78.1.238.
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Inhibitors of macromolecular synthesis in yeast.酵母中大分子合成的抑制剂。
Methods Cell Biol. 1975;12:17-38. doi: 10.1016/s0091-679x(08)60949-8.
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Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins.单端孢霉烯族真菌毒素抑制真核生物蛋白质合成的机制
Proc Natl Acad Sci U S A. 1974 Jan;71(1):30-4. doi: 10.1073/pnas.71.1.30.

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