Andoh R, Sakurada S, Kisara K, Takahashi M, Ohsawa K
Nihon Yakurigaku Zasshi. 1982 Apr;79(4):275-83.
Algesic actions of capsaicinoids were investigated by utilizing vocalization in conscious guinea pigs and medial thalamic neuronal activity in gallamine triethiodide immobilized cats. Intra-arterial administration of capsaicin and dihydrocapsaicin evoked strong vocalization response, but other capsaicinoids, nordihydrocapsaicin, homodihydrocapsaicin, homocapsaicin, norcapsaicin, N-(4-hydroxy-3-methoxybenzyl)-6-methylheptamide, and N-(4-hydroxy-3-methoxybenzyl)-6-methylhept-trans-4-enamide, were weaker than capsaicin and dihydrocapsaicin. Similar results were obtained from medial thalamic nociceptive neurons in cats. Morphine (10 mg/kg s.c.) suppressed vocalization response evoked by intra-arterial administration of capsaicin and bradykinin. Aspirin (100 mg/kg i.p.) also suppressed the bradykinin-evoked response, but not the capsaicin-evoked response. Capsi-amide, a non-pungent substance of Capsicum annuum L., failed to suppress nociceptive response to capsaicin or bradykinin in guinea pigs and cats. Tachyphylaxis was elicited by repeated administration of capsaicin in vocalization. No cross-tachyphylaxis to bradykinin, acetylcholine, and dihydrocapsaicin could be observed.
通过观察清醒豚鼠的发声以及三碘季铵酚麻醉猫的丘脑内侧神经元活动，研究了辣椒素类物质的致痛作用。动脉内注射辣椒素和二氢辣椒素可引起强烈的发声反应，但其他辣椒素类物质，如去甲二氢辣椒素、高双氢辣椒素、高辣椒素、降辣椒素、N-(4-羟基-3-甲氧基苄基)-6-甲基庚酰胺和N-(4-羟基-3-甲氧基苄基)-6-甲基庚-反式-4-烯酰胺，其作用比辣椒素和二氢辣椒素弱。在猫的丘脑内侧伤害性神经元中也得到了类似结果。吗啡（10mg/kg，皮下注射）可抑制动脉内注射辣椒素和缓激肽引起的发声反应。阿司匹林（100mg/kg，腹腔注射）也可抑制缓激肽引起的反应，但不能抑制辣椒素引起的反应。辣椒酰胺是辣椒的一种无辣味物质，不能抑制豚鼠和猫对辣椒素或缓激肽的伤害性反应。重复注射辣椒素可引起发声反应的快速耐受。对缓激肽、乙酰胆碱和二氢辣椒素未观察到交叉快速耐受现象。
