Fountain M W, Schultz R D
Immunobiology. 1982 May;161(5):409-14. doi: 10.1016/S0171-2985(82)80044-2.
Lymphocytes incubated with liposomes prior to the addition of phytohemagglutinin (PHA) exhibited a time dependent suppression of blastogenesis which was reversible for phosphatidylcholine (PC):cholesterol (Chol) alpha-tocopherol (alpha-T) (1:0.5:0.5), and PC: alpha-T (1:1) liposomes but not for PC and PC:Chol (1:1) liposomes. Incubation of PHA with lymphocytes prior to the addition of liposomes caused a time dependent, reversible suppression of blastogenesis for PC: alpha-T:Chol (1:0.5:0.5), PC: alpha-T (1:1) and PC:Chol (1:1) liposomes but not reversible for PC liposomes. The effects of phospholipid concentration on the blastogenic response to PHA exhibited a concentration dependent suppression from 1 to 2 mumoles phospholipid/ml which was reversible, to varying degrees, at a concentration of 4 mumoles phospholipid/ml.
在添加植物血凝素（PHA）之前用脂质体孵育的淋巴细胞表现出对增殖的时间依赖性抑制，这种抑制对于磷脂酰胆碱（PC）：胆固醇（Chol）：α-生育酚（α-T）（1:0.5:0.5）和PC：α-T（1:1）脂质体是可逆的，但对于PC和PC：Chol（1:1）脂质体则不可逆。在添加脂质体之前将PHA与淋巴细胞孵育会导致对PC：α-T：Chol（1:0.5:0.5）、PC：α-T（1:1）和PC：Chol（1:1）脂质体的增殖产生时间依赖性、可逆性抑制，但对PC脂质体则不可逆。磷脂浓度对PHA增殖反应的影响表现出从1至2微摩尔磷脂/毫升的浓度依赖性抑制，该抑制在4微摩尔磷脂/毫升的浓度下在不同程度上是可逆的。
