Munn C B, Ishiguro E E, Kay W W, Trust T J
Infect Immun. 1982 Jun;36(3):1069-75. doi: 10.1128/iai.36.3.1069-1075.1982.
The ability of virulent strains of Aeromonas salmonicida to resist the bactericidal activity of serum was quantitated. The A. salmonicida strains tested included virulent strains, mutants lacking the major surface A-protein, and mutants lacking A-protein and having a modified lipopolysaccharide structure. The sera evaluated included normal human, rabbit, and trout sera, immune trout serum, and immune rabbit serum containing antibodies to A-protein and lipopolysaccharide. Virulent strains of A. salmonicida displayed high or intermediate resistance to the bactericidal activity of complement both in the presence and absence of specific antibody. In normal sera, both A-protein and lipopolysaccharide contributed to serum resistance. In immune trout serum, the protection was conferred by A-protein.
对杀鲑气单胞菌强毒株抵抗血清杀菌活性的能力进行了定量分析。所测试的杀鲑气单胞菌菌株包括强毒株、缺乏主要表面A蛋白的突变体以及既缺乏A蛋白又具有修饰脂多糖结构的突变体。所评估的血清包括正常人血清、兔血清和鳟鱼血清、免疫鳟鱼血清以及含有针对A蛋白和脂多糖抗体的免疫兔血清。在有或没有特异性抗体的情况下，杀鲑气单胞菌强毒株对补体的杀菌活性均表现出高抗性或中等抗性。在正常血清中，A蛋白和脂多糖都有助于血清抗性。在免疫鳟鱼血清中，保护作用由A蛋白赋予。
