Peress N S, Tompkins D C
Invest Ophthalmol Vis Sci. 1982 Aug;23(2):168-75.
The pericapillary permeability of the ciliary processes to intravenously injected native (anionic) ferritin, neutral ferritin, and two cationic ferritin derivatives was studied in normal rats by electron microscopy. Anionic and neutral ferritin were largely confined to the circulatory compartment. Those particles that entered the pericapillary region of the ciliary processes were randomly scattered within the basal lamina. In contrast, cationic ferritin left the circulatory compartment and accumulated in the pericapillary region in association with the endothelium, the endothelial fenestrations, and the subendothelial basal lamina. The most cationic of the tracers used exhibited the greatest penetration and accumulation. The results indicate that the localization of tracer within the pericapillary region of the ciliary processes is directly related to the tracer's isoelectric point. The findings suggest that this region of the ciliary processes contains fixed anionic groups that influence its permeability.
通过电子显微镜研究了正常大鼠睫状体对静脉注射的天然（阴离子）铁蛋白、中性铁蛋白和两种阳离子铁蛋白衍生物的毛细血管周通透性。阴离子和中性铁蛋白主要局限于循环腔室。那些进入睫状体毛细血管周区域的颗粒随机散布在基膜内。相比之下，阳离子铁蛋白离开循环腔室，并与内皮、内皮窗孔和内皮下基膜相关联地积聚在毛细血管周区域。所用示踪剂中阳离子性最强的表现出最大的穿透和积聚。结果表明，示踪剂在睫状体毛细血管周区域的定位与示踪剂的等电点直接相关。这些发现提示，睫状体的该区域含有影响其通透性的固定阴离子基团。
