Nishikawa K, Ooi T
J Biochem. 1982 May;91(5):1821-4. doi: 10.1093/oxfordjournals.jbchem.a133877.
Amino acid compositions of 356 proteins are expressed as points in an 18 dimensional space of 18 axes representing the contents of amino acids. The proteins are classified into four groups of intra- and extracellular enzymes and nonenzymes according to analysis of the distribution of the points. The groups have a significant correlation to four folding types of secondary structures, and extra- and intracellular proteins to those with and without disulfide bond(s), respectively. The location and function of a protein seem to determine its amino acid composition and folding type.
356种蛋白质的氨基酸组成被表示为一个18维空间中的点，该空间有18个轴，分别代表氨基酸的含量。根据这些点的分布分析，这些蛋白质被分为细胞内酶、细胞外酶和非酶四类。这些类别与二级结构的四种折叠类型有显著相关性，细胞外和细胞内蛋白质分别与有和无二硫键的折叠类型相关。蛋白质的位置和功能似乎决定了其氨基酸组成和折叠类型。
