Jauzac P, Blasco A, Vigoni F, Valdiguie P, Bès A
J Cereb Blood Flow Metab. 1982 Sep;2(3):369-72. doi: 10.1038/jcbfm.1982.38.
Dopaminergic influence upon cerebral circulation was studied in 12 adult mongrel dogs, local cerebral blood flow (lCBF) being measured by the microspheres method. The intravenous injection of apomorphine (0.1 mg/kg) produced heterogeneous effects on lCBF; an increase in lCBF reaching the level of statistical significance was observed in frontal and sensory motor cortices, whereas blood flow was not significantly altered in the other regions examined. When the animals are considered individually, a widespread response was generally observed. Local cerebral blood flow increased from 16% to 85% (depending on the regions examined) in 4 animals, and tended to decrease (particularly in the caudate nucleus) in the 8 others. These opposite effects cannot be related with changes in general metabolic or hemodynamic parameters (PaCO2, PaO2, pH, and arterial pressure). It is thus concluded that the effect of dopaminergic stimulation upon cerebral circulation is more complex than previously reported. These effects could only be partly mediated via vascular receptors and could be the result of modifications of the local metabolic level.
在12只成年杂种犬中研究了多巴胺能对脑循环的影响，采用微球法测量局部脑血流量（lCBF）。静脉注射阿扑吗啡（0.1mg/kg）对lCBF产生了异质性影响；在额叶和感觉运动皮层观察到lCBF增加达到统计学显著水平，而在所检查的其他区域血流量没有显著改变。当对动物个体进行分析时，通常观察到广泛的反应。4只动物的局部脑血流量增加了16%至85%（取决于所检查的区域），另外8只动物的局部脑血流量则有下降趋势（特别是在尾状核）。这些相反的效应与一般代谢或血流动力学参数（PaCO2、PaO2、pH和动脉压）的变化无关。因此得出结论，多巴胺能刺激对脑循环的影响比以前报道的更为复杂。这些效应只能部分通过血管受体介导，可能是局部代谢水平改变的结果。
