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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

J Pharmacol. 1981 Nov-Dec;12(4):417-26.

The effects of dopamine and apomorphine were studied on the nutrient artery perfusion pressure in dog tibia after constant--flow autoperfusion of the nutrient artery for femoral arterial blood. The carotid arterial pressure was also recorded. 2. Dopamine always induced a rise in nutrient artery perfusion pressure which was reduced or abolished, but never reversed, by alpha-blocking drugs. 3. Apomorphine only elicited a weak and inconstant decrease in the nutrient artery perfusion pressure. Apomorphine vasodilatation was not antagonized by haloperidol, alpha-blocking drugs, sympathetic denervation, propranolol, atropine or mepyramine. Apomorphine induced a non-specific relaxation of the intraosseous vasculature. 4. Thus, this study found with dopamine only a vasoconstrictor effect. These results found no evidence for the existence of dopaminergic receptors in the intraosseous vascular bed.

在股动脉血液持续恒流自身灌注狗胫骨营养动脉后，研究了多巴胺和阿扑吗啡对狗胫骨营养动脉灌注压的影响。同时记录颈动脉压。2. 多巴胺总是引起营养动脉灌注压升高，α受体阻断药可使其降低或消除，但从未使其逆转。3. 阿扑吗啡仅引起营养动脉灌注压微弱且不稳定的下降。氟哌啶醇、α受体阻断药、交感神经去神经支配、普萘洛尔、阿托品或美吡拉敏均不能拮抗阿扑吗啡的血管舒张作用。阿扑吗啡引起骨内血管系统非特异性舒张。4. 因此，本研究发现多巴胺仅具有血管收缩作用。这些结果没有发现骨内血管床中存在多巴胺能受体的证据。

J Pharmacol. 1981 Nov-Dec;12(4):417-26.

The effects of dopamine and apomorphine were studied on the nutrient artery perfusion pressure in dog tibia after constant--flow autoperfusion of the nutrient artery for femoral arterial blood. The carotid arterial pressure was also recorded. 2. Dopamine always induced a rise in nutrient artery perfusion pressure which was reduced or abolished, but never reversed, by alpha-blocking drugs. 3. Apomorphine only elicited a weak and inconstant decrease in the nutrient artery perfusion pressure. Apomorphine vasodilatation was not antagonized by haloperidol, alpha-blocking drugs, sympathetic denervation, propranolol, atropine or mepyramine. Apomorphine induced a non-specific relaxation of the intraosseous vasculature. 4. Thus, this study found with dopamine only a vasoconstrictor effect. These results found no evidence for the existence of dopaminergic receptors in the intraosseous vascular bed.

在股动脉血液持续恒流自身灌注狗胫骨营养动脉后，研究了多巴胺和阿扑吗啡对狗胫骨营养动脉灌注压的影响。同时记录颈动脉压。2. 多巴胺总是引起营养动脉灌注压升高，α受体阻断药可使其降低或消除，但从未使其逆转。3. 阿扑吗啡仅引起营养动脉灌注压微弱且不稳定的下降。氟哌啶醇、α受体阻断药、交感神经去神经支配、普萘洛尔、阿托品或美吡拉敏均不能拮抗阿扑吗啡的血管舒张作用。阿扑吗啡引起骨内血管系统非特异性舒张。4. 因此，本研究发现多巴胺仅具有血管收缩作用。这些结果没有发现骨内血管床中存在多巴胺能受体的证据。