制动应激对自发性高血压大鼠脑血流量和脑血管通透性的影响。

Effects of immobilization stress on cerebral blood flow and cerebrovascular permeability in spontaneously hypertensive rats.

作者信息

Ohata M, Takei H, Fredericks W R, Rapoport S I

出版信息

J Cereb Blood Flow Metab. 1982 Sep;2(3):373-9. doi: 10.1038/jcbfm.1982.39.

DOI:10.1038/jcbfm.1982.39

Abstract

Immobilization of unanesthetized, freely breathing, 10-12 month-old, spontaneously hypertensive rats (SHR) did not significantly alter regional cerebral blood flow (rCBF) in 13 of 14 brain regions assayed. After 5 or 15 min of immobilization, rCBF was unchanged except at the frontal lobe, where it rose significantly by 21%. Furthermore, immobilization did not increase the cerebrovascular permeability-area product for 14C-sucrose, except at three brain regions. The results indicate that immobilization of SHR does not significantly affect rCBF or blood-brain barrier permeability in most regions of the brain, and suggest that adequate autoregulation of rCBF is maintained under stress.

摘要

对未麻醉、自由呼吸的10 - 12月龄自发性高血压大鼠（SHR）进行固定，在检测的14个脑区中的13个脑区，区域脑血流量（rCBF）未发生显著改变。在固定5分钟或15分钟后，除额叶rCBF显著升高21%外，其他脑区rCBF均未改变。此外，除三个脑区外，固定并未增加14C - 蔗糖的脑血管通透面积乘积。结果表明，对SHR进行固定在大脑的大多数区域不会显著影响rCBF或血脑屏障通透性，提示在应激状态下rCBF能维持充分的自身调节。