Oztaş Baria, Akgül Sibel, Arslan F Burcu
Department of Physiology, Istanbul Faculty of Medicine, Istanbul University, Capa-34390 Istanbul, Turkey.
Life Sci. 2004 Mar 5;74(16):1973-9. doi: 10.1016/j.lfs.2003.07.054.
Effect of surgical pain stress on the blood-brain barrier permeability was investigated in rats. The animals were divided into four groups: Group 1: control, Group 2: immobilization stress, Group 3: acute hypertension, Group 4: immobilization stress + surgical pain stress. Bilateral hid paw surgical wounds for cannulations were applied in animals' inguinal regions under diethyl-ether anesthesia, then the animals were awaken from anesthesia to produce surgical pain stress. Evans-blue was used as a blood-brain barrier tracer. There is no significantly blood-brain barrier breakdown after short-time immobilization stress, but after adrenalin hypertension blood-brain barrier permeability was increased especially on frontal and occipital cortices in 50% of the animals. Surgical pain stress increased blood-brain barrier permeabiliy in comparison to acute adrenalin-induced hypertension (p < 0.01). In surgical pain stress-induced animals distinct Evans-blue leakage was observed in the occipital, frontal and parieto-temporal cortices.
研究了手术疼痛应激对大鼠血脑屏障通透性的影响。将动物分为四组：第一组：对照组；第二组：制动应激组；第三组：急性高血压组；第四组：制动应激 + 手术疼痛应激组。在乙醚麻醉下，于动物腹股沟区制作双侧后爪手术伤口用于插管，然后使动物从麻醉中苏醒以产生手术疼痛应激。用伊文思蓝作为血脑屏障示踪剂。短时间制动应激后血脑屏障无明显破坏，但肾上腺素性高血压后，50% 的动物血脑屏障通透性增加，尤其是额叶和枕叶皮质。与急性肾上腺素诱导的高血压相比，手术疼痛应激增加了血脑屏障通透性（p < 0.01）。在手术疼痛应激诱导的动物中，在枕叶、额叶和顶颞叶皮质观察到明显的伊文思蓝渗漏。
