气相色谱法测定血液中的1,2 - 丙二醇二硝酸酯
Gas chromatographic determination of 1,2-propanediol dinitrate in blood.
作者信息
Erk S D, Jarboe C H, Newton P E, Pfledderer C
出版信息
J Chromatogr. 1982 May 7;240(1):117-23. doi: 10.1016/s0021-9673(01)84012-7.
A method is described for determination of 1,2-propanediol dinitrate in blood at concentrations ranging from 10 ng/ml up to 25,000 ng/ml. It used double ether extraction with manual shaking in order to complete sample preparation within 5 min. Samples are analyzed via gas chromatography-electron-capture detection using a column of 3% base deactivated SP-2250 on Supelcoport. This column provides excellent separation and little 1,2-propanediol dinitrate tailing.
本文描述了一种测定血液中浓度范围为10纳克/毫升至25,000纳克/毫升的1,2 - 丙二醇二硝酸酯的方法。该方法采用手动振荡双醚萃取，以便在5分钟内完成样品制备。样品通过气相色谱 - 电子捕获检测进行分析，使用在Supelcoport上涂覆3%碱失活SP - 2250的色谱柱。该色谱柱具有出色的分离效果，且1,2 - 丙二醇二硝酸酯拖尾现象少。
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