雄激素抵抗家族中的定性受体缺陷：成纤维细胞胞质雄激素受体的稳定失败。 - Suppr

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超能文献

Qualitative receptor defects in families with androgen resistance: failure of stabilization of the fibroblast cytosol androgen receptor.

作者信息

Griffin J E, Durrant J L

出版信息

J Clin Endocrinol Metab. 1982 Sep;55(3):465-74. doi: 10.1210/jcem-55-3-465.

DOI:10.1210/jcem-55-3-465

PMID:7096535

Abstract

摘要

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Qualitative receptor defects in families with androgen resistance: failure of stabilization of the fibroblast cytosol androgen receptor.雄激素抵抗家族中的定性受体缺陷：成纤维细胞胞质雄激素受体的稳定失败。

J Clin Endocrinol Metab. 1982 Sep;55(3):465-74. doi: 10.1210/jcem-55-3-465.

Defective androgen action at the cellular level in the androgen resistance syndromes. I. Differences between the complete and incomplete testicular feminization syndromes.雄激素抵抗综合征中细胞水平的雄激素作用缺陷。I. 完全型和不完全型睾丸女性化综合征之间的差异。

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Incomplete androgen insensitivity syndrome: partially masculinized genitalia in two patients with absence of androgen receptor in cultured fibroblasts.不完全雄激素不敏感综合征：两名培养的成纤维细胞中缺乏雄激素受体患者的生殖器部分男性化。

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J Clin Endocrinol Metab. 1982 Jul;55(1):61-9. doi: 10.1210/jcem-55-1-61.

[Syndromes of resistance to androgens].[雄激素抵抗综合征]

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Human minimal androgen insensitivity with normal dihydrotestosterone-binding capacity in cultured genital skin fibroblasts: evidence for an androgen-selective qualitative abnormality of the receptor.培养的生殖器皮肤成纤维细胞中具有正常二氢睾酮结合能力的人类最小雄激素不敏感：雄激素受体选择性定性异常的证据。

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A specific and rapid determination of human skin dihydrotestosterone cytosol receptor.

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Some properties of the specific androgen-binding activities in cultured human genital skin fibroblasts.培养的人外生殖器皮肤成纤维细胞中特异性雄激素结合活性的一些特性

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Pituitary apoplexy developed in a patient with androgen insensitivity syndrome.

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Molecular genetics of human androgen insensitivity.人类雄激素不敏感的分子遗传学

Eur J Pediatr. 1993;152 Suppl 2:S62-9. doi: 10.1007/BF02125442.

The androgen resistance syndromes: clinical and biochemical aspects.雄激素抵抗综合征：临床与生化方面

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Amino acid substitutions in the hormone-binding domain of the human androgen receptor alter the stability of the hormone receptor complex.人类雄激素受体激素结合域中的氨基酸取代会改变激素受体复合物的稳定性。

J Clin Invest. 1994 Oct;94(4):1642-50. doi: 10.1172/JCI117507.

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Expression of a mutant androgen receptor in cloned fibroblasts derived from a heterozygous carrier for the syndrome of testicular feminization.在源自睾丸女性化综合征杂合携带者的克隆成纤维细胞中突变雄激素受体的表达。

Am J Hum Genet. 1983 May;35(3):376-84.

High dose androgen therapy in male pseudohermaphroditism due to 5 alpha-reductase deficiency and disorders of the androgen receptor.高剂量雄激素疗法治疗因5α-还原酶缺乏和雄激素受体异常所致的男性假两性畸形。

J Clin Invest. 1984 Oct;74(4):1496-508. doi: 10.1172/JCI111563.

A mutation that causes lability of the androgen receptor under conditions that normally promote transformation to the DNA-binding state.一种在通常促进向DNA结合状态转变的条件下导致雄激素受体不稳定的突变。

J Clin Invest. 1984 Apr;73(4):1095-104. doi: 10.1172/JCI111295.

Impaired stimulation of 25-hydroxyvitamin D-24-hydroxylase in fibroblasts from a patient with vitamin D-dependent rickets, type II. A form of receptor-positive resistance to 1,25-dihydroxyvitamin D3.II型维生素D依赖性佝偻病患者成纤维细胞中25-羟基维生素D-24-羟化酶刺激受损。一种对1,25-二羟基维生素D3的受体阳性抵抗形式。

J Clin Invest. 1983 Oct;72(4):1190-9. doi: 10.1172/JCI111074.

Reduced affinity of the androgen receptor for 5 alpha-dihydrotestosterone but not methyltrienolone in a form of partial androgen resistance. Studies on cultured genital skin fibroblasts.在一种部分雄激素抵抗形式中，雄激素受体对5α - 双氢睾酮的亲和力降低，但对甲基三烯olone的亲和力未降低。对培养的生殖器皮肤成纤维细胞的研究。

J Clin Invest. 1985 Apr;75(4):1291-6. doi: 10.1172/JCI111829.

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