Tyndall R L, Clapp N K, Davidson K A, Colyer S P, Burtis C A
Chem Biol Interact. 1978 Nov;23(2):159-69. doi: 10.1016/0009-2797(78)90003-0.
Esterase profiles of plasma from female BALB/c mice treated with a variety of carcinogenic and weakly- or non-carcinogenic chemicals were analyzed. Mice treated with the potent carcinogens diethylnitrosamine, dinitrosopiperazine, dipropylnitrosamine, dimethylhydrazine, urethane, and dimethyldinitrosopiperazine had similarly altered plasma esterase profiles after 7 days' exposure to the chemicals. The alterations consisted of increased activity in 4 esterase bands. The increased activity persisted in some of the bands after cessation of carcinogen exposure. Exposure to high concentrations of the weakly- or non-carcinogenic compounds nitrosohydroxyproline, nitrosomethoxymethylamine, 1-nitroso-4methylpiperazine,nitroso-2,6dimethylpiperidine, and ethyl methanesulfonate caused no obvious plasma esterase alterations. Ingestion of carbon tetrachloride resulted in increased activity in one esterase band with concomitant decrease in a second band. Analysis of serum from test mice for levels of serum glutamic oxaloacetic transaminase, alkaline phosphatase, lactate dehydrogenase-lactate substrate, and D-gamma-glutamyl transpeptidase did not differentiate between mice treated with selected carcinogens and those treated with non-carcinogens and/or carbon tetrachloride.
分析了用多种致癌、弱致癌或非致癌化学物质处理的雌性BALB/c小鼠血浆的酯酶谱。用强致癌物二乙基亚硝胺、二亚硝基哌嗪、二丙基亚硝胺、二甲基肼、氨基甲酸乙酯和二甲基二亚硝基哌嗪处理的小鼠，在接触这些化学物质7天后，血浆酯酶谱有类似改变。这些改变包括4条酯酶带的活性增加。在致癌物接触停止后，某些带中的活性增加仍持续存在。接触高浓度的弱致癌或非致癌化合物亚硝基羟脯氨酸、亚硝基甲氧基甲胺、1-亚硝基-4-甲基哌嗪、亚硝基-2,6-二甲基哌啶和甲磺酸乙酯未引起明显的血浆酯酶改变。摄入四氯化碳导致一条酯酶带的活性增加，同时另一条带的活性降低。对受试小鼠血清中的血清谷氨酸草酰乙酸转氨酶、碱性磷酸酶、乳酸脱氢酶-乳酸底物和D-γ-谷氨酰转肽酶水平进行分析，未能区分用选定致癌物处理的小鼠与用非致癌物和/或四氯化碳处理的小鼠。
