Davidson K A, Tyndall R L, Clapp N K
Chem Biol Interact. 1978 Apr;21(1):19-27. doi: 10.1016/0009-2797(78)90065-0.
Selected non-specific plasma esterases in female BALB/c mice, separated by polyacrylamide gel electrophoresis, were qualitatively altered following treatment of the mice with diethylnitrosamine (DEN). These alterations include a decreased preference for naphthyl butyrate as a substrate relative to naphthyl acetate; decreased sensitivity to enhancement by divalent cations such as Ca2+, Mg2+, and Mn2; and an increased sensitivity to inhibition by eserine. All esterase species affected were also quantitatively altered and some were testosterone-dependent.
通过聚丙烯酰胺凝胶电泳分离的雌性BALB/c小鼠中选定的非特异性血浆酯酶，在用二乙基亚硝胺（DEN）处理小鼠后发生了定性改变。这些改变包括相对于萘乙酸，对丁酸萘酯作为底物的偏好降低；对Ca2+、Mg2+和Mn2+等二价阳离子增强作用的敏感性降低；以及对毒扁豆碱抑制作用的敏感性增加。所有受影响的酯酶种类在数量上也发生了改变，并且一些是依赖睾酮的。
