Meyer U, Wenk H, Ott T, Wetzel W
J Hirnforsch. 1982;23(1):1-12.
Acquisition and retention of a visual discrimination task as well as changes in the exploratory activity and emotional state of the animals were investigated in rats with different lesions in the telencephalic septal area. The cholinergic deafferentiation of the hippocampal formation due to the lesion was determined by quantitative histochemical estimations of the loss in acetylcholine esterase activity in the various subfields of the hippocampus and the results were correlated to the behavioral experiments. Total bilateral septal lesion resulted mainly in an impairment of the acquisition processes of the discrimination task combined with an enhancement of the retention index. Slight tendencies for attenuated activity in the exploratory and emotional behavior were also present in this group. Assymmetric septal lesions leaving one lateral septal nucleus undamaged caused higher activities in the exploratory and emotional behavior. Some enhancement of the retention index was found, too. The degree of cholinergic innervation of the hippocampus was partially involved in the behavioral effects.
在端脑隔区有不同损伤的大鼠中，研究了视觉辨别任务的习得与保持，以及动物探索活动和情绪状态的变化。通过对海马体各个亚区乙酰胆碱酯酶活性损失的定量组织化学评估，确定由于损伤导致的海马结构胆碱能去传入，并将结果与行为实验相关联。双侧完全隔区损伤主要导致辨别任务习得过程受损，同时保持指数增强。该组在探索和情绪行为方面也有活动减弱的轻微趋势。保留一侧外侧隔核未受损的不对称隔区损伤导致探索和情绪行为活动增加。还发现保持指数有所增强。海马体胆碱能神经支配程度部分参与了行为效应。
