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X线照射后脊髓白质的迟发性梗死

Delayed infarction of spinal cord white matter following x-irradiation.

作者信息

Blakemore W F, Palmer A C

出版信息

J Pathol. 1982 Aug;137(4):273-80. doi: 10.1002/path.1711370402.

DOI:10.1002/path.1711370402
PMID:7097400
Abstract

The thoraco-lumbar spinal cord of 4 cats were subjected to 4000 RADS of X-irradiation. Between 3 and 5 mth afterwards the animals developed weakness of the hind-legs and became uncoordinated. Small infarcts were found in the white matter of the irradiated area of spinal cord, accompanied by neuronal death and oedema of the grey matter close to the central canal. Ultrastructurally the infarcts were shown to stem from necrosis and thrombosis of small blood vessels. Comparison is made with the pathogenesis of spinal cord infarction that occurs in decompression sickness.

摘要

对4只猫的胸腰段脊髓进行了4000拉德的X射线照射。在照射后3至5个月期间,这些动物出现后肢无力和运动不协调。在脊髓照射区域的白质中发现了小梗死灶,伴有神经元死亡和中央管附近灰质的水肿。超微结构显示梗死灶源于小血管的坏死和血栓形成。并与减压病中发生的脊髓梗死的发病机制进行了比较。

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引用本文的文献

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Fibrocartilaginous embolism: a comprehensive review of an under-studied cause of spinal cord infarction and proposed diagnostic criteria.纤维软骨栓塞:对脊髓梗死研究不足的病因进行全面综述并提出诊断标准。
J Spinal Cord Med. 2016;39(2):146-54. doi: 10.1080/10790268.2015.1116726. Epub 2015 Dec 17.
2
Radiation-induced damage in the central nervous system: an interpretation of target cell responses.辐射诱发的中枢神经系统损伤:靶细胞反应解读
Br J Cancer Suppl. 1986;7:207-17.
3
A reappraisal of the roles of glial and vascular elements in the development of white matter necrosis in irradiated rat spinal cord.
对胶质细胞和血管成分在大鼠脊髓照射后白质坏死发展中作用的重新评估。
Br J Cancer Suppl. 1986;7:221-3.