Palmoski M J, Brandt K D
J Rheumatol. 1982 Mar-Apr;9(2):189-97.
Canine knee cartilage which had been damaged by laceration with a scalpel down to subchondral bone (Model A) and knee cartilage from dogs in whom osteoarthritis had been induced by transection of the anterior cruciate ligament by arthrotomy (Model B) were compared 7 weeks after the surgical procedures. Cartilage from the operated knees in Model A was hypocellular and showed extensive fibrosis, while samples from Model B showed moderate fibrillation and osteophyte formation. (In both cases water content was increased and uronic acid content decreased in cartilage from the operated knees.) Despite the much greater pathomorphologic changes in Model A, aggregation of 35S proteoglycans synthesized in culture was unchanged by the operation, while in Model B the proportion of proteoglycans existing as aggregates was diminished.
将手术刀切割至软骨下骨造成撕裂损伤的犬膝关节软骨（模型A），与通过关节切开术切断前交叉韧带诱导骨关节炎的犬的膝关节软骨（模型B），在手术操作7周后进行比较。模型A中手术膝关节的软骨细胞数量减少且呈现广泛纤维化，而模型B的样本显示中度纤维化和骨赘形成。（在两种情况下，手术膝关节软骨的含水量增加而糖醛酸含量降低。）尽管模型A的病理形态学变化大得多，但培养中合成的35S蛋白聚糖的聚集并未因手术而改变，而在模型B中，以聚集体形式存在的蛋白聚糖比例减少。
