Marchand B, Benezra C
J Med Chem. 1982 Jun;25(6):650-3. doi: 10.1021/jm00348a008.
A "double-head" hapten containing a pyrocatechol and an alpha-methylene-gamma-butyrolactone moiety (3) and "monofunctional haptens" with either one of these moieties (18 and 19) connected by a six-carbon chain have been synthesized, and their sensitizing capacity was tested on guinea pigs. In the "double-head" hapten, only the pyrocatechol end is "recognized". A possible interpretation of the biological results is offered.
已经合成了一种含有儿茶酚和α-亚甲基-γ-丁内酯部分的“双头”半抗原（3）以及通过六碳链连接的具有这些部分之一（18和19）的“单功能半抗原”，并在豚鼠身上测试了它们的致敏能力。在“双头”半抗原中，只有儿茶酚末端被“识别”。文中给出了对生物学结果的一种可能解释。
